Characterizing EPR-mediated passive drug targeting using contrast-enhanced functional ultrasound imaging

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F14%3A00427396" target="_blank" >RIV/61389013:_____/14:00427396 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.jconrel.2014.03.007" target="_blank" >http://dx.doi.org/10.1016/j.jconrel.2014.03.007</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jconrel.2014.03.007" target="_blank" >10.1016/j.jconrel.2014.03.007</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Characterizing EPR-mediated passive drug targeting using contrast-enhanced functional ultrasound imaging

Popis výsledku v původním jazyce

The Enhanced Permeability and Retention (EPR) effect is extensively used in drug delivery research. Taking into account that EPR is a highly variable phenomenon, we have here set out to evaluate if contrast-enhanced functional ultrasound (ceUS) imaging can be employed to characterize EPR-mediated passive drug targeting to tumors. Using standard fluorescence molecular tomography (FMT) and two different protocols for hybrid computed tomography-fluorescence molecular tomography (CT-FMT), the tumor accumulation of a 10 nm-sized near-infrared-fluorophore-labeled polymeric drug carrier (pHPMA-Dy750) was evaluated in CT26 tumor-bearing mice. In the same set of animals, two different ceUS techniques (2D MIOT and 3D B-mode imaging) were employed to assess tumorvascularization. Subsequently, the degree of tumor vascularization was correlated with the degree of EPR-mediated drug targeting. Depending on the optical imaging protocol used, the tumor accumulation of the polymeric drug carrier ranged

Název v anglickém jazyce

Characterizing EPR-mediated passive drug targeting using contrast-enhanced functional ultrasound imaging

Popis výsledku anglicky

The Enhanced Permeability and Retention (EPR) effect is extensively used in drug delivery research. Taking into account that EPR is a highly variable phenomenon, we have here set out to evaluate if contrast-enhanced functional ultrasound (ceUS) imaging can be employed to characterize EPR-mediated passive drug targeting to tumors. Using standard fluorescence molecular tomography (FMT) and two different protocols for hybrid computed tomography-fluorescence molecular tomography (CT-FMT), the tumor accumulation of a 10 nm-sized near-infrared-fluorophore-labeled polymeric drug carrier (pHPMA-Dy750) was evaluated in CT26 tumor-bearing mice. In the same set of animals, two different ceUS techniques (2D MIOT and 3D B-mode imaging) were employed to assess tumorvascularization. Subsequently, the degree of tumor vascularization was correlated with the degree of EPR-mediated drug targeting. Depending on the optical imaging protocol used, the tumor accumulation of the polymeric drug carrier ranged

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CD - Makromolekulární chemie

OECD FORD obor

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Projekt

<a href="/cs/project/GCP207%2F12%2FJ030" target="_blank" >GCP207/12/J030: Vysoce účinná polymerní terapeutika na bázi nanonosičů reagujících na vnější stimuly</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Controlled Release

ISSN

0168-3659

e-ISSN

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Svazek periodika

182

Číslo periodika v rámci svazku

28 May

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

7

Strana od-do

83-89

Kód UT WoS článku

000335554000009

EID výsledku v databázi Scopus

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