Exploiting end group functionalization for the design of antifouling bioactive brushes

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F14%3A00428662" target="_blank" >RIV/61389013:_____/14:00428662 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1039/C4PY00281D" target="_blank" >http://dx.doi.org/10.1039/C4PY00281D</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1039/C4PY00281D" target="_blank" >10.1039/C4PY00281D</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Exploiting end group functionalization for the design of antifouling bioactive brushes

Popis výsledku v původním jazyce

Biologically active surfaces are essential in many applications in the fields of biosensing, bioimplants, and tissue engineering. However, the introduction of bioactive motifs without impairment of their ability to resist non-specific interactions with biological media remains a challenge. Herein, we present a straightforward, facile strategy for the creation of bioactive surfaces based on the end-group biofunctionalization of state-of-the-art polymer brushes via an ultra-fast Diels?Alder ?click reaction. Surface-initiated atom transfer radical polymerization is employed to grow antifouling polymers preserving the end groups. These groups are then further converted to a reactive cyclopentadienyl moiety and exploited for the immobilization of biomolecules on the topmost layer of the brush. The minimal chemical modification of the antifouling polymer brush accounts for the full preservation of the fouling resistance of the surface even after biofunctionalization, which is critical for th

Název v anglickém jazyce

Exploiting end group functionalization for the design of antifouling bioactive brushes

Popis výsledku anglicky

Biologically active surfaces are essential in many applications in the fields of biosensing, bioimplants, and tissue engineering. However, the introduction of bioactive motifs without impairment of their ability to resist non-specific interactions with biological media remains a challenge. Herein, we present a straightforward, facile strategy for the creation of bioactive surfaces based on the end-group biofunctionalization of state-of-the-art polymer brushes via an ultra-fast Diels?Alder ?click reaction. Surface-initiated atom transfer radical polymerization is employed to grow antifouling polymers preserving the end groups. These groups are then further converted to a reactive cyclopentadienyl moiety and exploited for the immobilization of biomolecules on the topmost layer of the brush. The minimal chemical modification of the antifouling polymer brush accounts for the full preservation of the fouling resistance of the surface even after biofunctionalization, which is critical for th

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CD - Makromolekulární chemie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Polymer Chemistry

ISSN

1759-9954

e-ISSN

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Svazek periodika

5

Číslo periodika v rámci svazku

13

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

8

Strana od-do

4124-4131

Kód UT WoS článku

000337097500023

EID výsledku v databázi Scopus

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