Polymer therapeutics for treatment of viral infections such as Ebola - how to teach new tricks to an old dog? A hypothesis

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F14%3A00437495" target="_blank" >RIV/61389013:_____/14:00437495 - isvavai.cz</a>

Výsledek na webu

<a href="http://mmsl.cz/viCMS/soubory/pdf/MMSL_2014_4_5_WWW.pdf" target="_blank" >http://mmsl.cz/viCMS/soubory/pdf/MMSL_2014_4_5_WWW.pdf</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Polymer therapeutics for treatment of viral infections such as Ebola - how to teach new tricks to an old dog? A hypothesis

Popis výsledku v původním jazyce

Polymer drug delivery systems were during last few decades proven to be efficient potential therapeutics for cancer treatment, especilly for the treatment of solid tumors, where they may take advantage of the Enhanced Permeability and Retention (EPR) effect for tumor-specific passive accumulation. Controlled release of anticancer drugs in cancer cells may be triggered by. e.g., cathepsin B activation after endocytosis. Endosomal proteases, especially cathepsins B and L, are known to be one of the key factors influencing some viral infections. For instance Ebola virus requires partial proteolysis of its surface glycoprotein for efficient endosome escape within its life cycle. We hypothesize that polymeric cathepsin B and L inhibitors may utilize advantages of polymer delivery systems for more effective treatment of viral infections with cathepsin inhibitors reducing systemic toxicity and increasing efficacy by targeted delivery of these inhibitors.

Název v anglickém jazyce

Polymer therapeutics for treatment of viral infections such as Ebola - how to teach new tricks to an old dog? A hypothesis

Popis výsledku anglicky

Polymer drug delivery systems were during last few decades proven to be efficient potential therapeutics for cancer treatment, especilly for the treatment of solid tumors, where they may take advantage of the Enhanced Permeability and Retention (EPR) effect for tumor-specific passive accumulation. Controlled release of anticancer drugs in cancer cells may be triggered by. e.g., cathepsin B activation after endocytosis. Endosomal proteases, especially cathepsins B and L, are known to be one of the key factors influencing some viral infections. For instance Ebola virus requires partial proteolysis of its surface glycoprotein for efficient endosome escape within its life cycle. We hypothesize that polymeric cathepsin B and L inhibitors may utilize advantages of polymer delivery systems for more effective treatment of viral infections with cathepsin inhibitors reducing systemic toxicity and increasing efficacy by targeted delivery of these inhibitors.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EE - Mikrobiologie, virologie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Military Medical Science Letters

ISSN

0372-7025

e-ISSN

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Svazek periodika

83

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

5

Strana od-do

178-182

Kód UT WoS článku

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EID výsledku v databázi Scopus

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