Thermoresponsive polymer system based on poly(N-vinylcaprolactam) intended for local radiotherapy applications

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F15%3A00439963" target="_blank" >RIV/61389013:_____/15:00439963 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.apradiso.2015.01.005" target="_blank" >http://dx.doi.org/10.1016/j.apradiso.2015.01.005</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.apradiso.2015.01.005" target="_blank" >10.1016/j.apradiso.2015.01.005</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Thermoresponsive polymer system based on poly(N-vinylcaprolactam) intended for local radiotherapy applications

Popis výsledku v původním jazyce

Brachytherapy represents effective local therapy of unresectable solid tumors with very few side effects. Radiolabeled thermoresponsive polymers offer almost noninvasive approach to brachytherapy applications. A radioiodinated, water-soluble, thermosensitive poly(N-vinylcaprolactam) (PVCL) polymer was prepared using two approaches. The direct copolymerization with N-methacryloyl-l-tyrosinamide, as well as end-capping of carboxy-terminated PVCL homopolymer with tyramine, were used. In both cases the product was successfully radiolabeled with 125I. The obtained polymers demonstrate cloud-point temperature (TC) values in the range of 33?35 °C in all the studied solvent systems (water, PBS (pH 7.4) and physiological saline solution). Above the cloud pointtemperature, the molecularly dissolved polymer is macroprecipitated from the solution. The TC values close to the human body temperature of this biocompatible poly(N-vinylcaprolactam) polymer makes it a promising material intended for loc

Název v anglickém jazyce

Thermoresponsive polymer system based on poly(N-vinylcaprolactam) intended for local radiotherapy applications

Popis výsledku anglicky

Brachytherapy represents effective local therapy of unresectable solid tumors with very few side effects. Radiolabeled thermoresponsive polymers offer almost noninvasive approach to brachytherapy applications. A radioiodinated, water-soluble, thermosensitive poly(N-vinylcaprolactam) (PVCL) polymer was prepared using two approaches. The direct copolymerization with N-methacryloyl-l-tyrosinamide, as well as end-capping of carboxy-terminated PVCL homopolymer with tyramine, were used. In both cases the product was successfully radiolabeled with 125I. The obtained polymers demonstrate cloud-point temperature (TC) values in the range of 33?35 °C in all the studied solvent systems (water, PBS (pH 7.4) and physiological saline solution). Above the cloud pointtemperature, the molecularly dissolved polymer is macroprecipitated from the solution. The TC values close to the human body temperature of this biocompatible poly(N-vinylcaprolactam) polymer makes it a promising material intended for loc

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CD - Makromolekulární chemie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Applied Radiation and Isotopes

ISSN

0969-8043

e-ISSN

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Svazek periodika

98

Číslo periodika v rámci svazku

April

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

6

Strana od-do

7-12

Kód UT WoS článku

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EID výsledku v databázi Scopus

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