Increasing the density of nanomedicines improves their ultrasound-mediated delivery to tumours

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F15%3A00444229" target="_blank" >RIV/61389013:_____/15:00444229 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.jconrel.2015.05.265" target="_blank" >http://dx.doi.org/10.1016/j.jconrel.2015.05.265</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jconrel.2015.05.265" target="_blank" >10.1016/j.jconrel.2015.05.265</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Increasing the density of nanomedicines improves their ultrasound-mediated delivery to tumours

Popis výsledku v původním jazyce

Nanomedicines have provided fresh impetus in the fight against cancer due to their selectivity and power. However, these agents are limited when delivered intravenously due to their rapid clearance from the bloodstream and poor passage from the bloodstream into target tumours. Here we describe a novel stealthing strategy which addresses both these limitations and thereby demonstrate that both the passive and mechanically-mediated tumour accumulation of the model nanomedicine adenovirus (Ad) can be substantially enhanced. In our strategy gold nanoparticles were thoroughly modified with 2 kDa polyethyleneglycol (PEG) and then linked to Ad via a single reduction-cleavable 5 kDa PEG. The resulting Ad?gold?PEG construct was compared to non-modified Ad or conventionally stealthed Ad?poly[N-(2-hydroxypropyl)methacrylamide] (Ad?PHPMA). Notably, although Ad?gold?PEG was of similar size and surface charge to Ad?PHPMA the increase in density, resulting from the inclusion of the gold nanoparticles

Název v anglickém jazyce

Increasing the density of nanomedicines improves their ultrasound-mediated delivery to tumours

Popis výsledku anglicky

Nanomedicines have provided fresh impetus in the fight against cancer due to their selectivity and power. However, these agents are limited when delivered intravenously due to their rapid clearance from the bloodstream and poor passage from the bloodstream into target tumours. Here we describe a novel stealthing strategy which addresses both these limitations and thereby demonstrate that both the passive and mechanically-mediated tumour accumulation of the model nanomedicine adenovirus (Ad) can be substantially enhanced. In our strategy gold nanoparticles were thoroughly modified with 2 kDa polyethyleneglycol (PEG) and then linked to Ad via a single reduction-cleavable 5 kDa PEG. The resulting Ad?gold?PEG construct was compared to non-modified Ad or conventionally stealthed Ad?poly[N-(2-hydroxypropyl)methacrylamide] (Ad?PHPMA). Notably, although Ad?gold?PEG was of similar size and surface charge to Ad?PHPMA the increase in density, resulting from the inclusion of the gold nanoparticles

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CE - Biochemie

OECD FORD obor

—

Projekt

<a href="/cs/project/EE2.3.30.0029" target="_blank" >EE2.3.30.0029: BIOPOL: BIOpolymerní POstdoktorandská Laboratoř a vzdělávácí centrum</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Controlled Release

ISSN

0168-3659

e-ISSN

—

Svazek periodika

210

Číslo periodika v rámci svazku

28 July

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

9

Strana od-do

10-18

Kód UT WoS článku

000356238700002

EID výsledku v databázi Scopus

2-s2.0-84929611293