Macroporous biodegradable cryogels of synthetic poly(.alpha.-amino acids)

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F15%3A00450082" target="_blank" >RIV/61389013:_____/15:00450082 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1021/acs.biomac.5b01224" target="_blank" >http://dx.doi.org/10.1021/acs.biomac.5b01224</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1021/acs.biomac.5b01224" target="_blank" >10.1021/acs.biomac.5b01224</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Macroporous biodegradable cryogels of synthetic poly(.alpha.-amino acids)

Popis výsledku v původním jazyce

We present an investigation of the preparation of highly porous hydrogels based on biodegradable synthetic poly(?-amino acid) as potential tissue engineering scaffolds. Covalently cross-linked gels with permanent pores were formed under cryogenic conditions by free-radical copolymerization of poly[N5-(2-hydroxyethyl)-l-glutamine-stat-N5-(2-methacryloyl-oxy-ethyl)-l-glutamine] (PHEG-MA) with 2-hydrohyethyl methacrylate (HEMA) and, optionally, N-propargyl acrylamide (PrAAm) as minor comonomers. The morphology of the cryogels showed interconnected polyhedral or laminar pores. The volume content of communicating water-filled pores was >90%. The storage moduli of the swollen cryogels were in the range of 1?6 kPa, even when the water content was >95%. The enzymatic degradation of a cryogel corresponded to the decrease in its storage modulus during incubation with papain, a model enzyme with specificity analogous to wound-healing enzymes. It was shown that cryogels with incorporated alkyne gr

Název v anglickém jazyce

Macroporous biodegradable cryogels of synthetic poly(.alpha.-amino acids)

Popis výsledku anglicky

We present an investigation of the preparation of highly porous hydrogels based on biodegradable synthetic poly(?-amino acid) as potential tissue engineering scaffolds. Covalently cross-linked gels with permanent pores were formed under cryogenic conditions by free-radical copolymerization of poly[N5-(2-hydroxyethyl)-l-glutamine-stat-N5-(2-methacryloyl-oxy-ethyl)-l-glutamine] (PHEG-MA) with 2-hydrohyethyl methacrylate (HEMA) and, optionally, N-propargyl acrylamide (PrAAm) as minor comonomers. The morphology of the cryogels showed interconnected polyhedral or laminar pores. The volume content of communicating water-filled pores was >90%. The storage moduli of the swollen cryogels were in the range of 1?6 kPa, even when the water content was >95%. The enzymatic degradation of a cryogel corresponded to the decrease in its storage modulus during incubation with papain, a model enzyme with specificity analogous to wound-healing enzymes. It was shown that cryogels with incorporated alkyne gr

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CD - Makromolekulární chemie

OECD FORD obor

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Projekt

<a href="/cs/project/GAP108%2F12%2F1538" target="_blank" >GAP108/12/1538: MIKROSTRUKTUROVANÉ HYDROGELY PRO TKÁŇOVÉ INŽENÝRSTVÍ: VISKOELASTICKÉ ODEZVY GELU O RUZNÉ MORFOLOGICKÉ STRUKTUŘE.</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Biomacromolecules

ISSN

1525-7797

e-ISSN

—

Svazek periodika

16

Číslo periodika v rámci svazku

11

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

11

Strana od-do

3455-3465

Kód UT WoS článku

000364614300005

EID výsledku v databázi Scopus

2-s2.0-84946763643