Baicalin loaded in folate-PEG modified liposomes for enhanced stability and tumor targeting
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F16%3A00456084" target="_blank" >RIV/61389013:_____/16:00456084 - isvavai.cz</a>
Výsledek na webu
<a href="http://dx.doi.org/10.1016/j.colsurfb.2015.11.018" target="_blank" >http://dx.doi.org/10.1016/j.colsurfb.2015.11.018</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.colsurfb.2015.11.018" target="_blank" >10.1016/j.colsurfb.2015.11.018</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Baicalin loaded in folate-PEG modified liposomes for enhanced stability and tumor targeting
Popis výsledku v původním jazyce
Bioavailability of baicalin (BAI), an example of traditional Chinese medicine, has been modified by loading into liposome. Several liposome systems of different composition i.e., lipid/cholesterol (L), long-circulating stealth liposome (L-PEG) and folate receptor (FR)—targeted liposome (L-FA) have been used as the drug carrier for BAI. The obtained liposomes were around 80 nm in diameter with proper zeta potentials about 25 mV and sufficient physical stability in 3 months. The entrapment efficiency and loading efficiency of BAI in the liposomes were 41.0–46.4% and 8.8–10.0%, respectively. The morphology details of BAI lipsosome systems i.e., formation of small unilamellar vesicles, have been determined by cryogenic transmission electron microscopy (cryo-TEM) and small angle X-ray scattering (SAXS). In vitro cytotoxicity of BAI liposomes against HeLa cells was evaluated by MTT assay. BAI loaded FR-targeted liposomes showed higher cytotoxicity and cellular uptake compared with non-targeted liposomes. The results suggested that L-FA-BAI could enhance anti-tumor efficiency and should be an effective FR-targeted carrier system for BAI delivery.
Název v anglickém jazyce
Baicalin loaded in folate-PEG modified liposomes for enhanced stability and tumor targeting
Popis výsledku anglicky
Bioavailability of baicalin (BAI), an example of traditional Chinese medicine, has been modified by loading into liposome. Several liposome systems of different composition i.e., lipid/cholesterol (L), long-circulating stealth liposome (L-PEG) and folate receptor (FR)—targeted liposome (L-FA) have been used as the drug carrier for BAI. The obtained liposomes were around 80 nm in diameter with proper zeta potentials about 25 mV and sufficient physical stability in 3 months. The entrapment efficiency and loading efficiency of BAI in the liposomes were 41.0–46.4% and 8.8–10.0%, respectively. The morphology details of BAI lipsosome systems i.e., formation of small unilamellar vesicles, have been determined by cryogenic transmission electron microscopy (cryo-TEM) and small angle X-ray scattering (SAXS). In vitro cytotoxicity of BAI liposomes against HeLa cells was evaluated by MTT assay. BAI loaded FR-targeted liposomes showed higher cytotoxicity and cellular uptake compared with non-targeted liposomes. The results suggested that L-FA-BAI could enhance anti-tumor efficiency and should be an effective FR-targeted carrier system for BAI delivery.
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
CF - Fyzikální chemie a teoretická chemie
OECD FORD obor
—
Návaznosti výsledku
Projekt
<a href="/cs/project/GC15-10527J" target="_blank" >GC15-10527J: Sférický „kůň ve vakuu“, anebo použitelné micely? Chování a tvar nanočástic – protirakovinných nosičů léčiv ve skutečném prostředí krve.</a><br>
Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2016
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Colloids and Surfaces B-Biointerfaces
ISSN
0927-7765
e-ISSN
—
Svazek periodika
140
Číslo periodika v rámci svazku
1 April
Stát vydavatele periodika
NL - Nizozemsko
Počet stran výsledku
9
Strana od-do
74-82
Kód UT WoS článku
000371445500009
EID výsledku v databázi Scopus
2-s2.0-84951753939