Mannan-based conjugates as a multimodal imaging platform for lymph nodes

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F18%3A00489337" target="_blank" >RIV/61389013:_____/18:00489337 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00023001:_____/18:00076907

Výsledek na webu

<a href="http://dx.doi.org/10.1039/C7TB02888A" target="_blank" >http://dx.doi.org/10.1039/C7TB02888A</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1039/C7TB02888A" target="_blank" >10.1039/C7TB02888A</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Mannan-based conjugates as a multimodal imaging platform for lymph nodes

Popis výsledku v původním jazyce

We show that mannan-based conjugates possess exceptional features for multimodal imaging because of their biocompatibility, biodegradability and self-targeting properties. Two new mannan conjugates, containing a gadolinium complex and a fluorescent probe, one based only on polysaccharide and the other one comprising polysaccharide with poly(2-methyl-2-oxazoline) grafts, were prepared and simultaneously visualized in vitro and in vivo by magnetic resonance and fluorescence imaging. The synthesis of these mannan-based complexes was based on alkylation with allyl bromide or grafting with poly(2-methyl-2-oxazoline) chains, followed by a thiol–ene click reaction with cysteamine to introduce primary amino groups into their structure. Finally, the obtained conjugates were functionalized with contrast labels using the corresponding N-hydroxysuccinimide esters. When used to detect lymph nodes, the polymers showed better imaging properties than a commercially available contrast agent.

Název v anglickém jazyce

Mannan-based conjugates as a multimodal imaging platform for lymph nodes

Popis výsledku anglicky

We show that mannan-based conjugates possess exceptional features for multimodal imaging because of their biocompatibility, biodegradability and self-targeting properties. Two new mannan conjugates, containing a gadolinium complex and a fluorescent probe, one based only on polysaccharide and the other one comprising polysaccharide with poly(2-methyl-2-oxazoline) grafts, were prepared and simultaneously visualized in vitro and in vivo by magnetic resonance and fluorescence imaging. The synthesis of these mannan-based complexes was based on alkylation with allyl bromide or grafting with poly(2-methyl-2-oxazoline) chains, followed by a thiol–ene click reaction with cysteamine to introduce primary amino groups into their structure. Finally, the obtained conjugates were functionalized with contrast labels using the corresponding N-hydroxysuccinimide esters. When used to detect lymph nodes, the polymers showed better imaging properties than a commercially available contrast agent.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30104 - Pharmacology and pharmacy

Projekt

<a href="/cs/project/NV15-25781A" target="_blank" >NV15-25781A: Nová nádorová diagnostika na bázi glykogenu jako tělu vlastního nanostrukturovaného nosiče</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Materials Chemistry B

ISSN

2050-750X

e-ISSN

—

Svazek periodika

6

Číslo periodika v rámci svazku

17

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

13

Strana od-do

2584-2596

Kód UT WoS článku

000431421800011

EID výsledku v databázi Scopus

2-s2.0-85046642638