Fluorophilic-lipophilic-hydrophilic poly(2-oxazoline) block copolymers as MRI contrast agents: from synthesis to self-assembly

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F18%3A00492559" target="_blank" >RIV/61389013:_____/18:00492559 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1021/acs.macromol.8b00957" target="_blank" >http://dx.doi.org/10.1021/acs.macromol.8b00957</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1021/acs.macromol.8b00957" target="_blank" >10.1021/acs.macromol.8b00957</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Fluorophilic-lipophilic-hydrophilic poly(2-oxazoline) block copolymers as MRI contrast agents: from synthesis to self-assembly

Popis výsledku v původním jazyce

This work focuses on the synthesis and self-assembly of triphilic poly(2-oxazoline) triblock copolymers with high fluorine content toward our future aim of developing poly(2-oxazoline) magnetic resonance imaging (MRI) contrast agents. A highly fluorinated 2-substituted-2-oxazoline monomer, namely 2-(1H,1H,2H,2H-perfluorooctyl)-2-oxazoline, was synthesized using the Grignard reaction. The polymerization kinetics of the synthesized monomer was studied, and it was used for the preparation of triblock copolymers with hydrophilic 2-methyl-2-oxazoline, hydrophobic 2-octyl-2-oxazoline, and fluorophilic blocks by cationic ring-opening polymerization yielding polymers with low relatively dispersity (1.2-1.4). The presence of the blocks with the different nature in one copolymer structure facilitated self-assembly of the copolymers in water and dimethyl sulfoxide as observed by dynamic light scattering, cryo-transmission electron microscopy, and small-angle neutron scattering. The nanoparticle morphology is strongly influenced by the order and length of each block and the nature of solvent, leading to nanoparticles with core-shell structure as confirmed by small-angle neutron scattering. The reported poly(2-oxazoline) block copolymers with high fluorine content have high potential for future development of MRI contrast agents.

Název v anglickém jazyce

Fluorophilic-lipophilic-hydrophilic poly(2-oxazoline) block copolymers as MRI contrast agents: from synthesis to self-assembly

Popis výsledku anglicky

This work focuses on the synthesis and self-assembly of triphilic poly(2-oxazoline) triblock copolymers with high fluorine content toward our future aim of developing poly(2-oxazoline) magnetic resonance imaging (MRI) contrast agents. A highly fluorinated 2-substituted-2-oxazoline monomer, namely 2-(1H,1H,2H,2H-perfluorooctyl)-2-oxazoline, was synthesized using the Grignard reaction. The polymerization kinetics of the synthesized monomer was studied, and it was used for the preparation of triblock copolymers with hydrophilic 2-methyl-2-oxazoline, hydrophobic 2-octyl-2-oxazoline, and fluorophilic blocks by cationic ring-opening polymerization yielding polymers with low relatively dispersity (1.2-1.4). The presence of the blocks with the different nature in one copolymer structure facilitated self-assembly of the copolymers in water and dimethyl sulfoxide as observed by dynamic light scattering, cryo-transmission electron microscopy, and small-angle neutron scattering. The nanoparticle morphology is strongly influenced by the order and length of each block and the nature of solvent, leading to nanoparticles with core-shell structure as confirmed by small-angle neutron scattering. The reported poly(2-oxazoline) block copolymers with high fluorine content have high potential for future development of MRI contrast agents.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10610 - Biophysics

Projekt

<a href="/cs/project/GA17-00973S" target="_blank" >GA17-00973S: Lipidová kubická fáze pro podávání léků a nanokrystalizaci</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Macromolecules

ISSN

0024-9297

e-ISSN

—

Svazek periodika

51

Číslo periodika v rámci svazku

15

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

10

Strana od-do

6047-6056

Kód UT WoS článku

000442185700061

EID výsledku v databázi Scopus

2-s2.0-85051520964