Striking effect of polymer end-group on C60 nanoparticle formation by high shear vibrational milling with alkyne-functionalized poly(2-oxazoline)s

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F19%3A00500763" target="_blank" >RIV/61389013:_____/19:00500763 - isvavai.cz</a>

Výsledek na webu

<a href="https://pubs.acs.org/doi/10.1021/acsmacrolett.8b00998" target="_blank" >https://pubs.acs.org/doi/10.1021/acsmacrolett.8b00998</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1021/acsmacrolett.8b00998" target="_blank" >10.1021/acsmacrolett.8b00998</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Striking effect of polymer end-group on C60 nanoparticle formation by high shear vibrational milling with alkyne-functionalized poly(2-oxazoline)s

Popis výsledku v původním jazyce

Buckminsterfullerene (C60) has a large potential for biomedical applications. However, the main challenge for the realization of its biomedical application potential is to overcome its extremely low water solubility. One approach is the coformulation with biocompatible water-soluble polymers, such as poly(2-oxazoline)s (PAOx), to form water-soluble C60 nanoparticles (NPs). However, uniform and defined NPs have only been obtained via a thin film hydration method or using cyclodextrin-functionalized PAOx. Here, we report the mechanochemical preparation of defined and stable C60:PAOx NPs by the introduction of a simple alkyne group as a polymer end-group. The presence of this alkyne bond is proven to be crucial in the mechanochemical synthesis of stable, defined sub-100 nm C60:PAOx NPs, with high C60 content up to 8.9 wt %.

Název v anglickém jazyce

Striking effect of polymer end-group on C60 nanoparticle formation by high shear vibrational milling with alkyne-functionalized poly(2-oxazoline)s

Popis výsledku anglicky

Buckminsterfullerene (C60) has a large potential for biomedical applications. However, the main challenge for the realization of its biomedical application potential is to overcome its extremely low water solubility. One approach is the coformulation with biocompatible water-soluble polymers, such as poly(2-oxazoline)s (PAOx), to form water-soluble C60 nanoparticles (NPs). However, uniform and defined NPs have only been obtained via a thin film hydration method or using cyclodextrin-functionalized PAOx. Here, we report the mechanochemical preparation of defined and stable C60:PAOx NPs by the introduction of a simple alkyne group as a polymer end-group. The presence of this alkyne bond is proven to be crucial in the mechanochemical synthesis of stable, defined sub-100 nm C60:PAOx NPs, with high C60 content up to 8.9 wt %.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10404 - Polymer science

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

ACS Macro Letters

ISSN

2161-1653

e-ISSN

—

Svazek periodika

8

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

5

Strana od-do

172-176

Kód UT WoS článku

000459948600015

EID výsledku v databázi Scopus

2-s2.0-85060605719