Synthesis of amphiphilic copolymers based on dendritic polyethylene grafted by polyhydroxyethylmethacrylate and polyhydroxypropylmethacrylate and their use for construction of nanoparticles

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F19%3A00503306" target="_blank" >RIV/61389013:_____/19:00503306 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60461373:22310/19:43918162

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S0014305719300643?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0014305719300643?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.eurpolymj.2019.03.029" target="_blank" >10.1016/j.eurpolymj.2019.03.029</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Synthesis of amphiphilic copolymers based on dendritic polyethylene grafted by polyhydroxyethylmethacrylate and polyhydroxypropylmethacrylate and their use for construction of nanoparticles

Popis výsledku v původním jazyce

By grafting from approach amphiphilic grafted copolymers with a hydrophobic core based on dendritic polyethylene and hydrophilic grafts of polyhydroxyethylmethacrylate (PHEMA) and polyhydroxypropylmethacrylate (PHPMA) were synthesized by tandem chain walking copolymerization and ATRP. Copolymers with molar mass 160–1400 kg/mol and ∼50–90% of hydrophilic grafts were obtained. Core-shell nanoparticles with very narrow size distribution were prepared from the copolymers by solvent displacement method. Particles diameter was efficiently regulated by molar mass of the copolymers in the range of 60–180 nm. We demonstrated that these nanoparticles can act as nanocontainers for hydrophobic Nile red dye, achieving up to 25% encapsulation efficiency. Dendritic polyethylene (dPE) nanoparticles with biocompatible polar PHEMA and PHPMA shell can find application in nanocatalysis and cargo delivery.

Název v anglickém jazyce

Synthesis of amphiphilic copolymers based on dendritic polyethylene grafted by polyhydroxyethylmethacrylate and polyhydroxypropylmethacrylate and their use for construction of nanoparticles

Popis výsledku anglicky

By grafting from approach amphiphilic grafted copolymers with a hydrophobic core based on dendritic polyethylene and hydrophilic grafts of polyhydroxyethylmethacrylate (PHEMA) and polyhydroxypropylmethacrylate (PHPMA) were synthesized by tandem chain walking copolymerization and ATRP. Copolymers with molar mass 160–1400 kg/mol and ∼50–90% of hydrophilic grafts were obtained. Core-shell nanoparticles with very narrow size distribution were prepared from the copolymers by solvent displacement method. Particles diameter was efficiently regulated by molar mass of the copolymers in the range of 60–180 nm. We demonstrated that these nanoparticles can act as nanocontainers for hydrophobic Nile red dye, achieving up to 25% encapsulation efficiency. Dendritic polyethylene (dPE) nanoparticles with biocompatible polar PHEMA and PHPMA shell can find application in nanocatalysis and cargo delivery.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10404 - Polymer science

Projekt

<a href="/cs/project/GA18-22059S" target="_blank" >GA18-22059S: MODIFIKACE VĚTVENÝCH POLYOLEFINŮ POLÁRNÍMI SKUPINAMI</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

European Polymer Journal

ISSN

0014-3057

e-ISSN

—

Svazek periodika

115

Číslo periodika v rámci svazku

June

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

8

Strana od-do

193-200

Kód UT WoS článku

000471736400022

EID výsledku v databázi Scopus

2-s2.0-85062915265