Thermoresponsive behavior of poly(DEGMA)-based copolymers. NMR and dynamic light scattering study of aqueous solutions

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F20%3A00520469" target="_blank" >RIV/61389013:_____/20:00520469 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S0014305719322645?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0014305719322645?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.eurpolymj.2020.109488" target="_blank" >10.1016/j.eurpolymj.2020.109488</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Thermoresponsive behavior of poly(DEGMA)-based copolymers. NMR and dynamic light scattering study of aqueous solutions

Popis výsledku v původním jazyce

We studied temperature behavior of diblock copolymers of poly[2-(2-methoxyethoxy)ethyl methacrylate] (PDEGMA) with poly(N-(2-hydroxypropyl)methacrylamide and a statistical copolymer PDEGMA-co-N-propargylmethacrylamide in aqueous solutions. NMR spectra and dynamic light scattering showed that the copolymers exhibit a reversible phase transition which depends on the composition of the block copolymer and slightly on polymer concentration. In contrast to statistical copolymer, different behavior of proton groups in polymer backbone (and in the nearest side chain OCH2 group) on the one hand and in other side chain groups of the PDEGMA on the other hand was observed for diblock copolymers. Additionally, two types of water molecules were detected in solutions of the diblock copolymers above the phase transition –“free” with long and “bound” with short spin-spin relaxation times T2. NOESY spectra indicate that a core- to- shell morphology is unlikely in these block copolymers. This report emphasizes the importance of understanding of the self-association of copolymers in solution on the molecular level and provides important information for the design of “smart” thermoresponsive polymer-based drug delivery systems.

Název v anglickém jazyce

Thermoresponsive behavior of poly(DEGMA)-based copolymers. NMR and dynamic light scattering study of aqueous solutions

Popis výsledku anglicky

We studied temperature behavior of diblock copolymers of poly[2-(2-methoxyethoxy)ethyl methacrylate] (PDEGMA) with poly(N-(2-hydroxypropyl)methacrylamide and a statistical copolymer PDEGMA-co-N-propargylmethacrylamide in aqueous solutions. NMR spectra and dynamic light scattering showed that the copolymers exhibit a reversible phase transition which depends on the composition of the block copolymer and slightly on polymer concentration. In contrast to statistical copolymer, different behavior of proton groups in polymer backbone (and in the nearest side chain OCH2 group) on the one hand and in other side chain groups of the PDEGMA on the other hand was observed for diblock copolymers. Additionally, two types of water molecules were detected in solutions of the diblock copolymers above the phase transition –“free” with long and “bound” with short spin-spin relaxation times T2. NOESY spectra indicate that a core- to- shell morphology is unlikely in these block copolymers. This report emphasizes the importance of understanding of the self-association of copolymers in solution on the molecular level and provides important information for the design of “smart” thermoresponsive polymer-based drug delivery systems.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10404 - Polymer science

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

European Polymer Journal

ISSN

0014-3057

e-ISSN

—

Svazek periodika

124

Číslo periodika v rámci svazku

5 February

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

14

Strana od-do

1-14

Kód UT WoS článku

000514024400018

EID výsledku v databázi Scopus

2-s2.0-85077471755