Suppression of neutrophilic inflammation can be modulated by the droplet size of anti-inflammatory nanoemulsions

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F20%3A00524042" target="_blank" >RIV/61389013:_____/20:00524042 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.futuremedicine.com/doi/10.2217/nnm-2019-0407" target="_blank" >https://www.futuremedicine.com/doi/10.2217/nnm-2019-0407</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2217/nnm-2019-0407" target="_blank" >10.2217/nnm-2019-0407</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Suppression of neutrophilic inflammation can be modulated by the droplet size of anti-inflammatory nanoemulsions

Popis výsledku v původním jazyce

We aimed to develop nanoemulsions containing phosphodiesterase 4 inhibitor rolipram with different droplet sizes, to evaluate the anti-inflammatory effect against activated neutrophils and a related lung injury. We prepared nanoemulsions of three different sizes, 68, 133 and 188 nm. The nanoemulsion inhibited the superoxide anion but not elastase release in primary human neutrophils. The large-sized nanoemulsions were mostly internalized by neutrophils, resulting in the reduction of intracellular Ca2+ half-life. The peripheral organ distribution of near-infrared dye-tagged nanoemulsions increased, following the decrease in droplet diameter. Rolipram entrapment into intravenous nanoemulsions ameliorated pulmonary inflammation. The smallest droplet size showed improvement, compared with the largest size. We established a foundation for the development of nanoemulsions against inflamed lung disease.

Název v anglickém jazyce

Suppression of neutrophilic inflammation can be modulated by the droplet size of anti-inflammatory nanoemulsions

Popis výsledku anglicky

We aimed to develop nanoemulsions containing phosphodiesterase 4 inhibitor rolipram with different droplet sizes, to evaluate the anti-inflammatory effect against activated neutrophils and a related lung injury. We prepared nanoemulsions of three different sizes, 68, 133 and 188 nm. The nanoemulsion inhibited the superoxide anion but not elastase release in primary human neutrophils. The large-sized nanoemulsions were mostly internalized by neutrophils, resulting in the reduction of intracellular Ca2+ half-life. The peripheral organ distribution of near-infrared dye-tagged nanoemulsions increased, following the decrease in droplet diameter. Rolipram entrapment into intravenous nanoemulsions ameliorated pulmonary inflammation. The smallest droplet size showed improvement, compared with the largest size. We established a foundation for the development of nanoemulsions against inflamed lung disease.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10404 - Polymer science

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Nanomedicine

ISSN

1743-5889

e-ISSN

—

Svazek periodika

15

Číslo periodika v rámci svazku

8

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

19

Strana od-do

773-791

Kód UT WoS článku

000526854700004

EID výsledku v databázi Scopus

2-s2.0-85083002848