Copolymer of N-(2-hydroxypropyl) methacrylamide and carboxybetaine methacrylamide, polymer brushes

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F20%3A00536426" target="_blank" >RIV/61389013:_____/20:00536426 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/67985882:_____/20:00536426

Výsledek na webu

<a href="https://worldwide.espacenet.com/publicationDetails/originalDocument?FT=D&date=20200408&DB=&locale=en_EP&CC=EP&NR=3292161B1&KC=B1&ND=4#" target="_blank" >https://worldwide.espacenet.com/publicationDetails/originalDocument?FT=D&date=20200408&DB=&locale=en_EP&CC=EP&NR=3292161B1&KC=B1&ND=4#</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Copolymer of N-(2-hydroxypropyl) methacrylamide and carboxybetaine methacrylamide, polymer brushes

Popis výsledku v původním jazyce

The present invention relates to the preparation and use of copolymers composed of N-(2-hydroxypropyl) methacrylamide (HPMAA) and carboxybetaine methacrylamide (CBMAA). The invention further describes polymer brushes having structure I S--R-polymer (I) wherein S is a substrate, R is a residue of a polymerization initiator or a RAFT agent bound to the substrate, and “polymer” is the copolymer of N-(2-hydroxypropyl) methacrylamide and carboxybetaine methacrylamide. Furthermore, production of these polymer brushes, containing random or block copolymers grafted to or from a substrate is described. The copolymer brushes are suitable for protecting substrates from deposition and/or adhesion of biological substances, and/or against thrombus formation. The brushes functionalized by covalent attachment of bioactive substances to CBMAA monomer units are particularly suitable for specific interaction with target biological substances which is not affected by nonspecific deposition of non-target compounds.

Název v anglickém jazyce

Copolymer of N-(2-hydroxypropyl) methacrylamide and carboxybetaine methacrylamide, polymer brushes

Popis výsledku anglicky

The present invention relates to the preparation and use of copolymers composed of N-(2-hydroxypropyl) methacrylamide (HPMAA) and carboxybetaine methacrylamide (CBMAA). The invention further describes polymer brushes having structure I S--R-polymer (I) wherein S is a substrate, R is a residue of a polymerization initiator or a RAFT agent bound to the substrate, and “polymer” is the copolymer of N-(2-hydroxypropyl) methacrylamide and carboxybetaine methacrylamide. Furthermore, production of these polymer brushes, containing random or block copolymers grafted to or from a substrate is described. The copolymer brushes are suitable for protecting substrates from deposition and/or adhesion of biological substances, and/or against thrombus formation. The brushes functionalized by covalent attachment of bioactive substances to CBMAA monomer units are particularly suitable for specific interaction with target biological substances which is not affected by nonspecific deposition of non-target compounds.

Druh

P - Patent

CEP obor

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OECD FORD obor

10404 - Polymer science

Projekt

<a href="/cs/project/GBP205%2F12%2FG118" target="_blank" >GBP205/12/G118: Nanobiofotonika pro medicínu budoucnosti</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Číslo patentu nebo vzoru

EP3292161

Vydavatel

EPO_1 -

Název vydavatele

European Patent Office

Místo vydání

Munich, The Hague, Berlin, Vienna, Brussels

Stát vydání

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Datum přijetí

8. 4. 2020

Název vlastníka

Ústav makromolekulární chemie AV ČR, v. v. i. - Ústav fotoniky a elektroniky AV ČR, v. v. i.

Způsob využití

A - Výsledek využívá pouze poskytovatel

Druh možnosti využití

A - K využití výsledku jiným subjektem je vždy nutné nabytí licence