PEG-neridronate-modified NaYF4:Gd3+,Yb3+,Tm3+/NaGdF4 core-shell upconverting nanoparticles for bimodal magnetic resonance/optical luminescence imaging

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F21%3A00543052" target="_blank" >RIV/61389013:_____/21:00543052 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00023001:_____/21:00081192 RIV/00216208:11120/21:43921672 RIV/60461373:22340/21:43922107 RIV/46747885:24530/21:00008890

Výsledek na webu

<a href="https://pubs.acs.org/doi/10.1021/acsomega.1c01313" target="_blank" >https://pubs.acs.org/doi/10.1021/acsomega.1c01313</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1021/acsomega.1c01313" target="_blank" >10.1021/acsomega.1c01313</a>

Jazyk výsledku

angličtina

Název v původním jazyce

PEG-neridronate-modified NaYF4:Gd3+,Yb3+,Tm3+/NaGdF4 core-shell upconverting nanoparticles for bimodal magnetic resonance/optical luminescence imaging

Popis výsledku v původním jazyce

Upconverting nanoparticles are attracting extensive interest as a multimodal imaging tool. In this work, we report on the synthesis and characterization of gadolinium-enriched upconverting nanoparticles for bimodal magnetic resonance and optical luminescence imaging. NaYF4:Gd3+,Yb3+,Tm3+ core upconverting nanoparticles were obtained by a thermal coprecipitation of lanthanide oleate precursors in the presence of oleic acid as a stabilizer. With the aim of improving the upconversion emission and increasing the amount of Gd3+ ions on the nanoparticle surface, a 2.5 nm NaGdF4 shell was grown by the epitaxial layer-by-layer strategy, resulting in the 26 nm core–shell nanoparticles. Both core and core–shell nanoparticles were coated with poly(ethylene glycol) (PEG)-neridronate (PEG-Ner) to have stable and well-dispersed upconverting nanoparticles in a biological medium. FTIR spectroscopy and thermogravimetric analysis indicated the presence of ∼20 wt % of PEG-Ner on the nanoparticle surface. The addition of inert NaGdF4 shell resulted in a total 26-fold enhancement of the emission under 980 nm excitation and also affected the T1 and T2 relaxation times. Both r1 and r2 relaxivities of PEG-Ner-modified nanoparticles were much higher compared to those of non-PEGylated particles, thus manifesting their potential as a diagnostic tool for magnetic resonance imaging. Together with the enhanced luminescence efficiency, upconverting nanoparticles might represent an efficient probe for bimodal in vitro and in vivo imaging of cells in regenerative medicine, drug delivery, and/or photodynamic therapy.

Název v anglickém jazyce

PEG-neridronate-modified NaYF4:Gd3+,Yb3+,Tm3+/NaGdF4 core-shell upconverting nanoparticles for bimodal magnetic resonance/optical luminescence imaging

Popis výsledku anglicky

Upconverting nanoparticles are attracting extensive interest as a multimodal imaging tool. In this work, we report on the synthesis and characterization of gadolinium-enriched upconverting nanoparticles for bimodal magnetic resonance and optical luminescence imaging. NaYF4:Gd3+,Yb3+,Tm3+ core upconverting nanoparticles were obtained by a thermal coprecipitation of lanthanide oleate precursors in the presence of oleic acid as a stabilizer. With the aim of improving the upconversion emission and increasing the amount of Gd3+ ions on the nanoparticle surface, a 2.5 nm NaGdF4 shell was grown by the epitaxial layer-by-layer strategy, resulting in the 26 nm core–shell nanoparticles. Both core and core–shell nanoparticles were coated with poly(ethylene glycol) (PEG)-neridronate (PEG-Ner) to have stable and well-dispersed upconverting nanoparticles in a biological medium. FTIR spectroscopy and thermogravimetric analysis indicated the presence of ∼20 wt % of PEG-Ner on the nanoparticle surface. The addition of inert NaGdF4 shell resulted in a total 26-fold enhancement of the emission under 980 nm excitation and also affected the T1 and T2 relaxation times. Both r1 and r2 relaxivities of PEG-Ner-modified nanoparticles were much higher compared to those of non-PEGylated particles, thus manifesting their potential as a diagnostic tool for magnetic resonance imaging. Together with the enhanced luminescence efficiency, upconverting nanoparticles might represent an efficient probe for bimodal in vitro and in vivo imaging of cells in regenerative medicine, drug delivery, and/or photodynamic therapy.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10404 - Polymer science

Projekt

<a href="/cs/project/GA19-00676S" target="_blank" >GA19-00676S: Biokompatibilní povrchově modifikované světlo-konvertující nanočástice pro terapii zhoubných nádorů</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

ACS Omega

ISSN

2470-1343

e-ISSN

2470-1343

Svazek periodika

6

Číslo periodika v rámci svazku

22

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

10

Strana od-do

14420-14429

Kód UT WoS článku

000661452700046

EID výsledku v databázi Scopus

2-s2.0-85108823448