Magnetic iron oxide particles for theranostics

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F22%3A00545664" target="_blank" >RIV/61389013:_____/22:00545664 - isvavai.cz</a>

Výsledek na webu

<a href="https://link.springer.com/chapter/10.1007%2F978-3-030-76235-3_4" target="_blank" >https://link.springer.com/chapter/10.1007%2F978-3-030-76235-3_4</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/978-3-030-76235-3_4" target="_blank" >10.1007/978-3-030-76235-3_4</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Magnetic iron oxide particles for theranostics

Popis výsledku v původním jazyce

For many years, magnetic particles attracted a lot of interest in many fields, mainly including biomedicine. Recently, development of innovative strategies to tune the unique properties of magnetic nanoparticles for specific applications as theranostic agents has become one of the most challenging goals. This paper provides an overview of the synthesis, modification, and functionalization of magnetic nano- and microparticles. Special attention was paid to iron oxide composites used in cell separations and theranostics, such as anticancer drug delivery, diagnosis, and/or therapy of autoimmune and brain disorders. Last, but not the least, phenolic compound-modified magnetic particles were used as antioxidants or silver-containing carriers as antibacterial agents in in vitro and in vivo studies. Magnetic microparticles can be also incorporated in biosensors, exemplified by thionine-conjugated magnetic poly(carboxymethyl methacrylate-co-ethylene dimethacrylate) particles that showed higher enzymatic activity than nonmagnetic particles. Magnetic nano- and microparticles were characterized by a range of physicochemical methods, including transmission electron microscopy, dynamic light scattering, vibrating sample magnetometry, and Fourier-transform infrared spectroscopy, in terms of determination of particle morphology (size and its distribution), specific surface area, magnetic, and chemical properties. The chemical composition and crystallinity were confirmed by X-ray photoelectron spectroscopy. Moreover, the interactions between the magnetic particles and cells and/or other biological species were described.

Název v anglickém jazyce

Magnetic iron oxide particles for theranostics

Popis výsledku anglicky

For many years, magnetic particles attracted a lot of interest in many fields, mainly including biomedicine. Recently, development of innovative strategies to tune the unique properties of magnetic nanoparticles for specific applications as theranostic agents has become one of the most challenging goals. This paper provides an overview of the synthesis, modification, and functionalization of magnetic nano- and microparticles. Special attention was paid to iron oxide composites used in cell separations and theranostics, such as anticancer drug delivery, diagnosis, and/or therapy of autoimmune and brain disorders. Last, but not the least, phenolic compound-modified magnetic particles were used as antioxidants or silver-containing carriers as antibacterial agents in in vitro and in vivo studies. Magnetic microparticles can be also incorporated in biosensors, exemplified by thionine-conjugated magnetic poly(carboxymethyl methacrylate-co-ethylene dimethacrylate) particles that showed higher enzymatic activity than nonmagnetic particles. Magnetic nano- and microparticles were characterized by a range of physicochemical methods, including transmission electron microscopy, dynamic light scattering, vibrating sample magnetometry, and Fourier-transform infrared spectroscopy, in terms of determination of particle morphology (size and its distribution), specific surface area, magnetic, and chemical properties. The chemical composition and crystallinity were confirmed by X-ray photoelectron spectroscopy. Moreover, the interactions between the magnetic particles and cells and/or other biological species were described.

Druh

C - Kapitola v odborné knize

CEP obor

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OECD FORD obor

10404 - Polymer science

Projekt

<a href="/cs/project/GC20-02177J" target="_blank" >GC20-02177J: Antioxidační magnetické nanočástice modifikované fenolickými sloučeninami pro léčení nemocí spojených s oxidačním stresem: Studie nano-biorozhraní</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Biomedical Nanomaterials

ISBN

978-3-030-76234-6

Počet stran výsledku

21

Strana od-do

95-115

Počet stran knihy

330

Název nakladatele

Springer

Místo vydání

Cham

Kód UT WoS kapitoly

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