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Biodegradable thermoplastic starch/polycaprolactone blends with co-continuous morphology suitable for local release of antibiotics

Identifikátory výsledku

  • Kód výsledku v IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F22%3A00552875" target="_blank" >RIV/61389013:_____/22:00552875 - isvavai.cz</a>

  • Nalezeny alternativní kódy

    RIV/00216305:26620/22:PU144217 RIV/00216208:11130/22:10438388 RIV/00064203:_____/22:10438388 RIV/00216208:11110/22:10438388

  • Výsledek na webu

    <a href="https://www.mdpi.com/1996-1944/15/3/1101" target="_blank" >https://www.mdpi.com/1996-1944/15/3/1101</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.3390/ma15031101" target="_blank" >10.3390/ma15031101</a>

Alternativní jazyky

  • Jazyk výsledku

    angličtina

  • Název v původním jazyce

    Biodegradable thermoplastic starch/polycaprolactone blends with co-continuous morphology suitable for local release of antibiotics

  • Popis výsledku v původním jazyce

    We report a reproducible preparation and characterization of highly homogeneous thermoplastic starch/pol(ε‑caprolactone) blends (TPS/PCL) with a minimal thermomechanical degradation and co-continuous morphology. These materials would be suitable for biomedical applications, specifically for the local release of antibiotics (ATB) from the TPS phase. The TPS/PCL blends were prepared in the whole concentration range. In agreement with theoretical predictions based on component viscosities, the co-continuous morphology was found for TPS/PCL blends with a composition of 70/30 wt.%. The minimal thermomechanical degradation of the blends was achieved by an optimization of the processing conditions and by keeping processing temperatures as low as possible, because higher temperatures might damage ATB in the final application. The blends’ homogeneity was verified by scanning electron microscopy. The co-continuous morphology was confirmed by submicron-computed tomography. The mechanical performance of the blends was characterized in both microscale (by an instrumented microindentation hardness testing, MHI) and macroscale (by dynamic thermomechanical analysis, DMTA). The elastic moduli of TPS increased ca four times in the TPS/PCL (70/30) blend. The correlations between elastic moduli measured by MHI and DMTA were very strong, which implied that, in the future studies, it would be possible to use just micromechanical testing that does not require large specimens.

  • Název v anglickém jazyce

    Biodegradable thermoplastic starch/polycaprolactone blends with co-continuous morphology suitable for local release of antibiotics

  • Popis výsledku anglicky

    We report a reproducible preparation and characterization of highly homogeneous thermoplastic starch/pol(ε‑caprolactone) blends (TPS/PCL) with a minimal thermomechanical degradation and co-continuous morphology. These materials would be suitable for biomedical applications, specifically for the local release of antibiotics (ATB) from the TPS phase. The TPS/PCL blends were prepared in the whole concentration range. In agreement with theoretical predictions based on component viscosities, the co-continuous morphology was found for TPS/PCL blends with a composition of 70/30 wt.%. The minimal thermomechanical degradation of the blends was achieved by an optimization of the processing conditions and by keeping processing temperatures as low as possible, because higher temperatures might damage ATB in the final application. The blends’ homogeneity was verified by scanning electron microscopy. The co-continuous morphology was confirmed by submicron-computed tomography. The mechanical performance of the blends was characterized in both microscale (by an instrumented microindentation hardness testing, MHI) and macroscale (by dynamic thermomechanical analysis, DMTA). The elastic moduli of TPS increased ca four times in the TPS/PCL (70/30) blend. The correlations between elastic moduli measured by MHI and DMTA were very strong, which implied that, in the future studies, it would be possible to use just micromechanical testing that does not require large specimens.

Klasifikace

  • Druh

    J<sub>imp</sub> - Článek v periodiku v databázi Web of Science

  • CEP obor

  • OECD FORD obor

    10404 - Polymer science

Návaznosti výsledku

  • Projekt

    Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

  • Návaznosti

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Ostatní

  • Rok uplatnění

    2022

  • Kód důvěrnosti údajů

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Údaje specifické pro druh výsledku

  • Název periodika

    Materials

  • ISSN

    1996-1944

  • e-ISSN

    1996-1944

  • Svazek periodika

    15

  • Číslo periodika v rámci svazku

    3

  • Stát vydavatele periodika

    CH - Švýcarská konfederace

  • Počet stran výsledku

    22

  • Strana od-do

    1101

  • Kód UT WoS článku

    000760870800001

  • EID výsledku v databázi Scopus

    2-s2.0-85123610917