Phase separation and pH-dependent behavior of four-arm star-shaped porphyrin-PNIPAM4 conjugates

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F22%3A00556292" target="_blank" >RIV/61389013:_____/22:00556292 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11320/22:10452650 RIV/00216208:11310/22:10452650

Výsledek na webu

<a href="https://pubs.acs.org/doi/10.1021/acs.macromol.1c02188" target="_blank" >https://pubs.acs.org/doi/10.1021/acs.macromol.1c02188</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1021/acs.macromol.1c02188" target="_blank" >10.1021/acs.macromol.1c02188</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Phase separation and pH-dependent behavior of four-arm star-shaped porphyrin-PNIPAM4 conjugates

Popis výsledku v původním jazyce

Star-shaped porphyrin-PNIPAM4 (PP) conjugates having four PNIPAM arms connected to a central tetraphenylporphyrin unit were synthesized using reversible addition–fragmentation chain-transfer polymerization. Temperature-induced phase-separation behavior of the conjugates was investigated, and the lower critical solution temperature (type II)–composition phase diagram was constructed using Flory–Huggins theory. Interestingly, in contrast to PNIPAM homopolymers, the shorter PNIPAM arms of PP conjugates lead to a lower phase-separation temperature (Tp). The concentration dependency of the size of the cooperative domain was also determined. Below Tp, experimental data indicate that PP behaves as a 1D supramolecular polymer with a concentration-dependent length, while above Tp, PP globules adopt a larger spherical shape. Various temperature–pH reversible and irreversible interdependencies (“cross-effects”) between phase separation and protonation were observed. The PP conjugates represent a dual temperature–pH-responsive model system possessing various aggregated states, making them candidates for visual indicators, pH or temperature sensors, or singlet oxygen generators for biomedical applications.

Název v anglickém jazyce

Phase separation and pH-dependent behavior of four-arm star-shaped porphyrin-PNIPAM4 conjugates

Popis výsledku anglicky

Star-shaped porphyrin-PNIPAM4 (PP) conjugates having four PNIPAM arms connected to a central tetraphenylporphyrin unit were synthesized using reversible addition–fragmentation chain-transfer polymerization. Temperature-induced phase-separation behavior of the conjugates was investigated, and the lower critical solution temperature (type II)–composition phase diagram was constructed using Flory–Huggins theory. Interestingly, in contrast to PNIPAM homopolymers, the shorter PNIPAM arms of PP conjugates lead to a lower phase-separation temperature (Tp). The concentration dependency of the size of the cooperative domain was also determined. Below Tp, experimental data indicate that PP behaves as a 1D supramolecular polymer with a concentration-dependent length, while above Tp, PP globules adopt a larger spherical shape. Various temperature–pH reversible and irreversible interdependencies (“cross-effects”) between phase separation and protonation were observed. The PP conjugates represent a dual temperature–pH-responsive model system possessing various aggregated states, making them candidates for visual indicators, pH or temperature sensors, or singlet oxygen generators for biomedical applications.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10404 - Polymer science

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Macromolecules

ISSN

0024-9297

e-ISSN

1520-5835

Svazek periodika

55

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

14

Strana od-do

2109-2122

Kód UT WoS článku

000775805500019

EID výsledku v databázi Scopus

2-s2.0-85126600773