Biocompatible hydrogels based on chitosan, cellulose/starch, PVA and PEDOT:PSS with high flexibility and high mechanical strength

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F22%3A00559150" target="_blank" >RIV/61389013:_____/22:00559150 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/67985823:_____/22:00559150 RIV/49777513:23640/22:43965967

Výsledek na webu

<a href="https://link.springer.com/article/10.1007/s10570-022-04686-4" target="_blank" >https://link.springer.com/article/10.1007/s10570-022-04686-4</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s10570-022-04686-4" target="_blank" >10.1007/s10570-022-04686-4</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Biocompatible hydrogels based on chitosan, cellulose/starch, PVA and PEDOT:PSS with high flexibility and high mechanical strength

Popis výsledku v původním jazyce

Fabricating mechanically strong hydrogels that can withstand the conditions in internal tissues is a challenging task. We have designed hydrogels based on multicomponent systems by combining chitosan, starch/cellulose, PVA, and PEDOT:PSS via one-pot synthesis. The starch-based hydrogels were homogeneous, while the cellulose-based hydrogels showed the presence of cellulose micro- and nanofibers. The cellulose-based hydrogels demonstrated a swelling ratio between 121 and 156%, while the starch-based hydrogels showed higher values, from 234 to 280%. Tensile tests indicated that the presence of starch in the hydrogels provided high flexibility (strain at break > 300%), while combination with cellulose led to the formation of stiffer hydrogels (elastic moduli 3.9–6.6 MPa). The ultimate tensile strength for both types of hydrogels was similar (2.8–3.9 MPa). The adhesion and growth of human osteoblast-like SAOS-2 cells was higher on hydrogels with cellulose than on hydrogels with starch, and was higher on hydrogels with PEDOT:PSS than on hydrogels without this polymer. The metabolic activity of cells cultivated for 3 days in the hydrogel infusions indicated that no acutely toxic compounds were released. This is promising for further possible applications of these hydrogels in tissue engineering or in wound dressings.

Název v anglickém jazyce

Biocompatible hydrogels based on chitosan, cellulose/starch, PVA and PEDOT:PSS with high flexibility and high mechanical strength

Popis výsledku anglicky

Fabricating mechanically strong hydrogels that can withstand the conditions in internal tissues is a challenging task. We have designed hydrogels based on multicomponent systems by combining chitosan, starch/cellulose, PVA, and PEDOT:PSS via one-pot synthesis. The starch-based hydrogels were homogeneous, while the cellulose-based hydrogels showed the presence of cellulose micro- and nanofibers. The cellulose-based hydrogels demonstrated a swelling ratio between 121 and 156%, while the starch-based hydrogels showed higher values, from 234 to 280%. Tensile tests indicated that the presence of starch in the hydrogels provided high flexibility (strain at break > 300%), while combination with cellulose led to the formation of stiffer hydrogels (elastic moduli 3.9–6.6 MPa). The ultimate tensile strength for both types of hydrogels was similar (2.8–3.9 MPa). The adhesion and growth of human osteoblast-like SAOS-2 cells was higher on hydrogels with cellulose than on hydrogels with starch, and was higher on hydrogels with PEDOT:PSS than on hydrogels without this polymer. The metabolic activity of cells cultivated for 3 days in the hydrogel infusions indicated that no acutely toxic compounds were released. This is promising for further possible applications of these hydrogels in tissue engineering or in wound dressings.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10404 - Polymer science

Projekt

<a href="/cs/project/GA20-01641S" target="_blank" >GA20-01641S: Degradovatelná nanocelulóza jako nová podpůrná struktura pro tkáňové inženýrství</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Cellulose

ISSN

0969-0239

e-ISSN

1572-882X

Svazek periodika

29

Číslo periodika v rámci svazku

12

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

21

Strana od-do

6697-6717

Kód UT WoS článku

000815422900001

EID výsledku v databázi Scopus

2-s2.0-85132706794