Magnetic poly(.epsilon.-caprolactone)-based nanocomposite membranes for bone cell engineering

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F22%3A00562259" target="_blank" >RIV/61389013:_____/22:00562259 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/67985823:_____/22:00562259

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S0304885322008526?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0304885322008526?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jmmm.2022.169967" target="_blank" >10.1016/j.jmmm.2022.169967</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Magnetic poly(.epsilon.-caprolactone)-based nanocomposite membranes for bone cell engineering

Popis výsledku v původním jazyce

Magnetic polymer nanocomposites manipulatable by an external magnetic field have a great potential for bone tissue regeneration. Various strategies have been proposed for their fabrication, as uniform distribution of magnetic nanoparticles (MNPs) within the polymer matrix remains to be the main challenge. The aim of this study was to design poly(ε-caprolactone) (PCL) matrix containing iron oxide nanoparticles stabilized by saturated fatty acids with the increasing number of carbon atoms, i.e., caprylic (CA), palmitic (PA), and stearic acids (SA). We investigated the effect of the type of fatty acid and the content of particles in nanocomposite membranes on their physicochemical properties and biological response toward the SAOS-2 cells. The incorporation of the MNPs in PCL matrix resulted in a gradual increase of Young’s modulus, a slight decrease of tensile strength, and a significant decrease of stress and strain at break. The addition of SA-stabilized MNPs (1 wt%) in the PCL matrix increased its strength. The membranes containing CA-stabilized MNPs remained non-toxic towards SAOS-2 cells, while the cytotoxicity of other nanocomposites increased with the enhanced length of carbon chains of fatty acids stabilizing MNPs, as well as with their increasing content in membranes.

Název v anglickém jazyce

Magnetic poly(.epsilon.-caprolactone)-based nanocomposite membranes for bone cell engineering

Popis výsledku anglicky

Magnetic polymer nanocomposites manipulatable by an external magnetic field have a great potential for bone tissue regeneration. Various strategies have been proposed for their fabrication, as uniform distribution of magnetic nanoparticles (MNPs) within the polymer matrix remains to be the main challenge. The aim of this study was to design poly(ε-caprolactone) (PCL) matrix containing iron oxide nanoparticles stabilized by saturated fatty acids with the increasing number of carbon atoms, i.e., caprylic (CA), palmitic (PA), and stearic acids (SA). We investigated the effect of the type of fatty acid and the content of particles in nanocomposite membranes on their physicochemical properties and biological response toward the SAOS-2 cells. The incorporation of the MNPs in PCL matrix resulted in a gradual increase of Young’s modulus, a slight decrease of tensile strength, and a significant decrease of stress and strain at break. The addition of SA-stabilized MNPs (1 wt%) in the PCL matrix increased its strength. The membranes containing CA-stabilized MNPs remained non-toxic towards SAOS-2 cells, while the cytotoxicity of other nanocomposites increased with the enhanced length of carbon chains of fatty acids stabilizing MNPs, as well as with their increasing content in membranes.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10404 - Polymer science

Projekt

<a href="/cs/project/GA20-07015S" target="_blank" >GA20-07015S: Magnetické kompozitní materiály pro neinvazivní stimulaci buněk v tkáňovém inženýrství</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Magnetism and Magnetic Materials

ISSN

0304-8853

e-ISSN

1873-4766

Svazek periodika

563

Číslo periodika v rámci svazku

1 December

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

11

Strana od-do

169967

Kód UT WoS článku

000871107000009

EID výsledku v databázi Scopus

2-s2.0-85138455635