Self-activated antibacterial MOF-based coating on medically relevant polypropylene

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F23%3A00570888" target="_blank" >RIV/61389013:_____/23:00570888 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60461373:22310/23:43926149 RIV/60461373:22330/23:43926149 RIV/60461373:22340/23:43926149 RIV/44555601:13440/23:43897692

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S0169433223007250?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0169433223007250?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.apsusc.2023.157048" target="_blank" >10.1016/j.apsusc.2023.157048</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Self-activated antibacterial MOF-based coating on medically relevant polypropylene

Popis výsledku v původním jazyce

Modern medicine is virtually unimaginable without using various auxiliary materials and devices such as catheters or implants. In this context, there is a potential risk of bacterial colonization and biofilm formation on the surface of these devices, which can lead to serious infections and endanger the health of patients. To prevent bacterial colonization, the preparation and utilization of an intelligent self-activating antibacterial coating on the surface of medically-relevant polypropylene (PP) are proposed in this work. The 3D periodic metal–organic framework structure (copper-1,3,5-benzenetricarboxylate, further referred as CuBTC) was covalently immobilized on the surface of the PP film. The immobilized CuBTC layer can effectively release NO• radicals from its endogenous donor – S-Nitrosoglutathion (GSNO). Local NO• generation ensures the surface antifouling properties and efficiently inhibits the bacterial adhesion to PP. Unlike materials requiring an external stimulus to activate their antibacterial properties, the proposed coating responds to increasing concentration of GSNO in body fluids (increasing of GSNO concentration is commonly associated with bacterial infection and inflammatory response). So that, the proposed coating can be efficiently self-activated on the right place and at the right time. Considering the application area of medical PP, we also estimated the stability of CuBTC antimicrobial response.

Název v anglickém jazyce

Self-activated antibacterial MOF-based coating on medically relevant polypropylene

Popis výsledku anglicky

Modern medicine is virtually unimaginable without using various auxiliary materials and devices such as catheters or implants. In this context, there is a potential risk of bacterial colonization and biofilm formation on the surface of these devices, which can lead to serious infections and endanger the health of patients. To prevent bacterial colonization, the preparation and utilization of an intelligent self-activating antibacterial coating on the surface of medically-relevant polypropylene (PP) are proposed in this work. The 3D periodic metal–organic framework structure (copper-1,3,5-benzenetricarboxylate, further referred as CuBTC) was covalently immobilized on the surface of the PP film. The immobilized CuBTC layer can effectively release NO• radicals from its endogenous donor – S-Nitrosoglutathion (GSNO). Local NO• generation ensures the surface antifouling properties and efficiently inhibits the bacterial adhesion to PP. Unlike materials requiring an external stimulus to activate their antibacterial properties, the proposed coating responds to increasing concentration of GSNO in body fluids (increasing of GSNO concentration is commonly associated with bacterial infection and inflammatory response). So that, the proposed coating can be efficiently self-activated on the right place and at the right time. Considering the application area of medical PP, we also estimated the stability of CuBTC antimicrobial response.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10404 - Polymer science

Projekt

<a href="/cs/project/GA21-06065S" target="_blank" >GA21-06065S: Nové funkcionalizované senzory založené na plazmonech jako nástroje pro monitorování buněk a pro pokročilé tkáňové inženýrství</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Applied Surface Science

ISSN

0169-4332

e-ISSN

1873-5584

Svazek periodika

623

Číslo periodika v rámci svazku

30 June

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

9

Strana od-do

157048

Kód UT WoS článku

000966033400001

EID výsledku v databázi Scopus

2-s2.0-85151021398