A smart nanopaper sensor for optical diagnosis of Helicobacter pylori infection

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F23%3A00576773" target="_blank" >RIV/61389013:_____/23:00576773 - isvavai.cz</a>

Výsledek na webu

<a href="https://pubs.rsc.org/en/content/articlelanding/2023/MA/D3MA00612C" target="_blank" >https://pubs.rsc.org/en/content/articlelanding/2023/MA/D3MA00612C</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1039/D3MA00612C" target="_blank" >10.1039/D3MA00612C</a>

Jazyk výsledku

angličtina

Název v původním jazyce

A smart nanopaper sensor for optical diagnosis of Helicobacter pylori infection

Popis výsledku v původním jazyce

Despite a decline in its prevalence, Helicobacter pylori (H. pylori), as the most common causative agent of chronic gastrointestinal diseases, still infects more than half of the world's population. Although effective, current H. pylori infection diagnostic approaches entail some drawbacks and hurdles, including requiring endoscopy and multiple biopsies, harmful chemicals, and expensive and bulky apparatus. Herein, to tackle some of state-of-the-art limitations, we have developed a biocompatible nanosensor for diagnosis of H. pylori infection. The developed optical sensor comprises NaYF4:Yb,Er,Lu@PEG-NH2 upconversion nanoparticles, red cabbage-extracted anthocyanins, and iron oxide nanoparticles embedded within chitin nanopaper. The enzymatic reaction of H. pylori urease enzyme with urea, which leads to pH changes, and consequently changes in the pH-dependent fluorescence/color profile of the developed sensor via an inner filter effect mechanism, was utilized as a sensing strategy for H. pylori infection diagnosis. A portable 3D-printed smartphone-based imaging platform was also fabricated for monitoring the developed sensor. We believe that our developed smart nanosensor can not only potentially be exploited as an ingestible sensor for non-invasive diagnosis of H. pylori infection, its therapeutic monitoring, and gastrointestinal pH monitoring, but also provide fresh insights into the development of a variety of innovative ingestible/swallowable sensors for non-invasive gastrointestinal diagnostics.

Název v anglickém jazyce

A smart nanopaper sensor for optical diagnosis of Helicobacter pylori infection

Popis výsledku anglicky

Despite a decline in its prevalence, Helicobacter pylori (H. pylori), as the most common causative agent of chronic gastrointestinal diseases, still infects more than half of the world's population. Although effective, current H. pylori infection diagnostic approaches entail some drawbacks and hurdles, including requiring endoscopy and multiple biopsies, harmful chemicals, and expensive and bulky apparatus. Herein, to tackle some of state-of-the-art limitations, we have developed a biocompatible nanosensor for diagnosis of H. pylori infection. The developed optical sensor comprises NaYF4:Yb,Er,Lu@PEG-NH2 upconversion nanoparticles, red cabbage-extracted anthocyanins, and iron oxide nanoparticles embedded within chitin nanopaper. The enzymatic reaction of H. pylori urease enzyme with urea, which leads to pH changes, and consequently changes in the pH-dependent fluorescence/color profile of the developed sensor via an inner filter effect mechanism, was utilized as a sensing strategy for H. pylori infection diagnosis. A portable 3D-printed smartphone-based imaging platform was also fabricated for monitoring the developed sensor. We believe that our developed smart nanosensor can not only potentially be exploited as an ingestible sensor for non-invasive diagnosis of H. pylori infection, its therapeutic monitoring, and gastrointestinal pH monitoring, but also provide fresh insights into the development of a variety of innovative ingestible/swallowable sensors for non-invasive gastrointestinal diagnostics.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10404 - Polymer science

Projekt

<a href="/cs/project/GA21-04420S" target="_blank" >GA21-04420S: Ochranné povlaky proti rozpouštění/rozpadu světlo-konvertujících nanočástic na bázi lanthanidů v biologických médiích</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Materials Advances

ISSN

2633-5409

e-ISSN

2633-5409

Svazek periodika

4

Číslo periodika v rámci svazku

20

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

10

Strana od-do

4965-4974

Kód UT WoS článku

001078532400001

EID výsledku v databázi Scopus

2-s2.0-85175092366