Well-defined poly(2-isopropenyl-2-oxazoline) brushes provide fouling resistance and versatility in surface functionalization

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F24%3A00588486" target="_blank" >RIV/61389013:_____/24:00588486 - isvavai.cz</a>

Výsledek na webu

<a href="https://pubs.rsc.org/en/content/articlelanding/2024/py/d4py00424h" target="_blank" >https://pubs.rsc.org/en/content/articlelanding/2024/py/d4py00424h</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1039/D4PY00424H" target="_blank" >10.1039/D4PY00424H</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Well-defined poly(2-isopropenyl-2-oxazoline) brushes provide fouling resistance and versatility in surface functionalization

Popis výsledku v původním jazyce

Poly(2-isopropenyl-2-oxazoline) (PIPOx), a biocompatible polymer amenable to clean and orthogonal post-polymerization modifications, has recently emerged as a suitable candidate for the preparation of functional polymer brushes via surface-initiated reversible-deactivation radical polymerization (SI RDRP). However, the field currently lacks a universal SI RDRP method that would provide a straightforward control over the PIPOx brush thickness and be applicable to non-planar surfaces. Herein, we designed an aqueous, metallic copper-mediated RDRP (Cu(0)-RDRP) protocol for SI grafting of IPOx that manifests an excellent degree of temporal control over the PIPOx brush thickness up to more than 100 nm. The superior kinetic control was achieved through the use of an all-chlorine initiation/catalytic Cu(0)-RDRP system and careful ligand selection, demonstrating a clear advantage over previous approaches based on brominated initiators. Additionally, we found that using neat water as a reaction medium for the Cu(0) catalyst generation in the standard disproportionation step significantly accelerates the brush growth. Importantly, a surface plasmon resonance analysis demonstrated for the first time the high resistance of PIPOx brushes against non-specific protein fouling, as documented by a significant (96%) decrease in protein deposition from undiluted blood plasma and negligible adsorption from fetal bovine serum and other protein solutions. Finally, we showcased in model scenarios the versatility of the prepared well-defined PIPOx brushes by modifying them with suitable functional carboxylic acids under mild conditions in order to subsequently synthesize graft copolymer brushes or trigger a CuAAC click reaction. Our results highlight PIPOx brushes as an attractive platform for the fabrication of low-fouling, multifunctional surfaces.

Název v anglickém jazyce

Well-defined poly(2-isopropenyl-2-oxazoline) brushes provide fouling resistance and versatility in surface functionalization

Popis výsledku anglicky

Poly(2-isopropenyl-2-oxazoline) (PIPOx), a biocompatible polymer amenable to clean and orthogonal post-polymerization modifications, has recently emerged as a suitable candidate for the preparation of functional polymer brushes via surface-initiated reversible-deactivation radical polymerization (SI RDRP). However, the field currently lacks a universal SI RDRP method that would provide a straightforward control over the PIPOx brush thickness and be applicable to non-planar surfaces. Herein, we designed an aqueous, metallic copper-mediated RDRP (Cu(0)-RDRP) protocol for SI grafting of IPOx that manifests an excellent degree of temporal control over the PIPOx brush thickness up to more than 100 nm. The superior kinetic control was achieved through the use of an all-chlorine initiation/catalytic Cu(0)-RDRP system and careful ligand selection, demonstrating a clear advantage over previous approaches based on brominated initiators. Additionally, we found that using neat water as a reaction medium for the Cu(0) catalyst generation in the standard disproportionation step significantly accelerates the brush growth. Importantly, a surface plasmon resonance analysis demonstrated for the first time the high resistance of PIPOx brushes against non-specific protein fouling, as documented by a significant (96%) decrease in protein deposition from undiluted blood plasma and negligible adsorption from fetal bovine serum and other protein solutions. Finally, we showcased in model scenarios the versatility of the prepared well-defined PIPOx brushes by modifying them with suitable functional carboxylic acids under mild conditions in order to subsequently synthesize graft copolymer brushes or trigger a CuAAC click reaction. Our results highlight PIPOx brushes as an attractive platform for the fabrication of low-fouling, multifunctional surfaces.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

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OECD FORD obor

10404 - Polymer science

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Polymer Chemistry

ISSN

1759-9954

e-ISSN

1759-9962

Svazek periodika

15

Číslo periodika v rámci svazku

32

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

11

Strana od-do

3300-3310

Kód UT WoS článku

001279745100001

EID výsledku v databázi Scopus

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