Polyvinylpyrrolidone-functionalized graphene oxide as a nanocarrier for dual-drug delivery of quercetin and curcumin against HeLa cancer cells

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F24%3A00598047" target="_blank" >RIV/61389013:_____/24:00598047 - isvavai.cz</a>

Výsledek na webu

<a href="https://4spepublications.onlinelibrary.wiley.com/doi/10.1002/vnl.22115" target="_blank" >https://4spepublications.onlinelibrary.wiley.com/doi/10.1002/vnl.22115</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/vnl.22115" target="_blank" >10.1002/vnl.22115</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Polyvinylpyrrolidone-functionalized graphene oxide as a nanocarrier for dual-drug delivery of quercetin and curcumin against HeLa cancer cells

Popis výsledku v původním jazyce

This study is to develop a nanocarrier based on polyvinylpyrrolidone (PVP)-functionalized graphene oxide (GO–PVP), loaded with both curcumin (CUR) and quercetin (QSR), and then its performance compared with nanocarriers carrying the drugs separately. The study also aimed to investigate the cytotoxic effects of these nanocarriers on HeLa cancer cells. To achieve this, GO was synthesized using a modified version of Hummer's method and subsequently functionalized with PVP. Drug loading onto the GO and GO–PVP nanocarriers was achieved through hydrophobic interactions. Furthermore, the ability of the nanocarriers to accommodate a single drug or a combination of drugs was examined. In our study, combined system shows higher drug loading, that is, 28.1% of QSR and 24.34% of CUR onto GO–PVP–QSR–CUR nanocarrier in comparison to single drug nanocarrier systems GO–PVP–QSR and GO–PVP–CUR which loaded 22.5% of QSR and 18.73% of CUR, respectively. Notably, the synthesized nanocarrier exhibited a pH-sensitive drug release pattern. These results collectively suggest that GO–PVP–CUR–QSR displayed significantly higher cytotoxicity against HeLa cancer cells compared to both single-drug nanocarrier systems at the specified concentrations. In addition, future pre-clinical and clinical studies to evaluate the safety and efficacy of GO–PVP–CUR–QSR for cancer treatment are strongly recommended.

Název v anglickém jazyce

Polyvinylpyrrolidone-functionalized graphene oxide as a nanocarrier for dual-drug delivery of quercetin and curcumin against HeLa cancer cells

Popis výsledku anglicky

This study is to develop a nanocarrier based on polyvinylpyrrolidone (PVP)-functionalized graphene oxide (GO–PVP), loaded with both curcumin (CUR) and quercetin (QSR), and then its performance compared with nanocarriers carrying the drugs separately. The study also aimed to investigate the cytotoxic effects of these nanocarriers on HeLa cancer cells. To achieve this, GO was synthesized using a modified version of Hummer's method and subsequently functionalized with PVP. Drug loading onto the GO and GO–PVP nanocarriers was achieved through hydrophobic interactions. Furthermore, the ability of the nanocarriers to accommodate a single drug or a combination of drugs was examined. In our study, combined system shows higher drug loading, that is, 28.1% of QSR and 24.34% of CUR onto GO–PVP–QSR–CUR nanocarrier in comparison to single drug nanocarrier systems GO–PVP–QSR and GO–PVP–CUR which loaded 22.5% of QSR and 18.73% of CUR, respectively. Notably, the synthesized nanocarrier exhibited a pH-sensitive drug release pattern. These results collectively suggest that GO–PVP–CUR–QSR displayed significantly higher cytotoxicity against HeLa cancer cells compared to both single-drug nanocarrier systems at the specified concentrations. In addition, future pre-clinical and clinical studies to evaluate the safety and efficacy of GO–PVP–CUR–QSR for cancer treatment are strongly recommended.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10404 - Polymer science

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Vinyl & Additive Technology

ISSN

1083-5601

e-ISSN

1548-0585

Svazek periodika

30

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

13

Strana od-do

1241-1253

Kód UT WoS článku

001220153000001

EID výsledku v databázi Scopus

2-s2.0-85192884537