Interpolyelectrolyte complexes of a biguanide cationic polyelectrolyte: formation of core/corona nanoparticles with double-hydrophilic diblock polyanion
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F24%3A00602502" target="_blank" >RIV/61389013:_____/24:00602502 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/00216208:11310/24:10488855
Výsledek na webu
<a href="https://pubs.rsc.org/en/content/articlelanding/2024/sm/d4sm00851k" target="_blank" >https://pubs.rsc.org/en/content/articlelanding/2024/sm/d4sm00851k</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1039/D4SM00851K" target="_blank" >10.1039/D4SM00851K</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Interpolyelectrolyte complexes of a biguanide cationic polyelectrolyte: formation of core/corona nanoparticles with double-hydrophilic diblock polyanion
Popis výsledku v původním jazyce
Biguanide-based cationic polyelectrolytes are used as key components of interpolyelectrolyte complexes bolstering alginate hydrogel microcapsules employed in cell therapies. Nevertheless, electrostatic complexation of these unique polycations has not been studied before. In this study, the interaction between biguanide condensates and anionic polyelectrolytes with carboxylate groups was studied on a model system of a metformin condensate (MFC) and an anionic diblock polyelectrolyte poly(methacrylic acid)-block-poly(ethylene oxide) (PMAA–PEO). The formation of MFC/PMAA–PEO core–corona nanoparticles was followed by static, dynamic and electrophoretic light scattering and by isothermal titration calorimetry and their internal structure was investigated by small angle neutron scattering and cryogenic transmission electron microscopy. It was found that the aggregation of PMAA–PEO chains induced by MFC occurred at much lower MFC/PMAA–PEO ratios that would correspond to the isoelectric point, thus yielding strongly negatively charged nanoparticles, suggesting the role of specific (non-electrostatic) interactions in the stabilization of the complex between PMAA and MFC.
Název v anglickém jazyce
Interpolyelectrolyte complexes of a biguanide cationic polyelectrolyte: formation of core/corona nanoparticles with double-hydrophilic diblock polyanion
Popis výsledku anglicky
Biguanide-based cationic polyelectrolytes are used as key components of interpolyelectrolyte complexes bolstering alginate hydrogel microcapsules employed in cell therapies. Nevertheless, electrostatic complexation of these unique polycations has not been studied before. In this study, the interaction between biguanide condensates and anionic polyelectrolytes with carboxylate groups was studied on a model system of a metformin condensate (MFC) and an anionic diblock polyelectrolyte poly(methacrylic acid)-block-poly(ethylene oxide) (PMAA–PEO). The formation of MFC/PMAA–PEO core–corona nanoparticles was followed by static, dynamic and electrophoretic light scattering and by isothermal titration calorimetry and their internal structure was investigated by small angle neutron scattering and cryogenic transmission electron microscopy. It was found that the aggregation of PMAA–PEO chains induced by MFC occurred at much lower MFC/PMAA–PEO ratios that would correspond to the isoelectric point, thus yielding strongly negatively charged nanoparticles, suggesting the role of specific (non-electrostatic) interactions in the stabilization of the complex between PMAA and MFC.
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
10404 - Polymer science
Návaznosti výsledku
Projekt
Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.
Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2024
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Soft Matter
ISSN
1744-683X
e-ISSN
1744-6848
Svazek periodika
20
Číslo periodika v rámci svazku
47
Stát vydavatele periodika
GB - Spojené království Velké Británie a Severního Irska
Počet stran výsledku
8
Strana od-do
9475-9482
Kód UT WoS článku
001359741600001
EID výsledku v databázi Scopus
2-s2.0-85209707594