Laser-induced photodynamic effect.

Kód výsledku v IS VaVaI

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Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Laser-induced photodynamic effect.

Popis výsledku v původním jazyce

Photodynamic therapy is a treatment that is used for destruction of certain tumors. The treatment is performed with photosensitizers that generate reactive oxygen species in the presence of light and oxygen. The absorption and fluorescence spectra of theClAlPcS2 and ZnPcS2 photosensitizers were measured. From this analysis a semiconductor laser emitting a beam of 50 mW cw power at the wavelength of 675 nm for our experiments was chosen, because this wavelength corresponded with the absorption maximum (675 nm) in long-wave region of the visible part of electromagnetic spectra. B16 (cells line of mouse melanoma) was chosen as a standard testing system for definition of the in vitro phototoxicity after photodynamic reaction. The optimal phototoxic effecton B16 cells was observed at 2 (mu) g/ml ClAlPcS2 in combination with laser irradiation of 10 J/cm2.

Název v anglickém jazyce

Laser-induced photodynamic effect.

Popis výsledku anglicky

Photodynamic therapy is a treatment that is used for destruction of certain tumors. The treatment is performed with photosensitizers that generate reactive oxygen species in the presence of light and oxygen. The absorption and fluorescence spectra of theClAlPcS2 and ZnPcS2 photosensitizers were measured. From this analysis a semiconductor laser emitting a beam of 50 mW cw power at the wavelength of 675 nm for our experiments was chosen, because this wavelength corresponded with the absorption maximum (675 nm) in long-wave region of the visible part of electromagnetic spectra. B16 (cells line of mouse melanoma) was chosen as a standard testing system for definition of the in vitro phototoxicity after photodynamic reaction. The optimal phototoxic effecton B16 cells was observed at 2 (mu) g/ml ClAlPcS2 in combination with laser irradiation of 10 J/cm2.

Druh

C - Kapitola v odborné knize

CEP obor

BO - Biofyzika

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2001

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Laser Florence 2000: A window on the laser Medicine World (Proceedings of SPIE, vol. 4606).

ISBN

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Počet stran výsledku

4

Strana od-do

144-147

Počet stran knihy

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Název nakladatele

The International Society for Optical Engineering

Místo vydání

Cincinaty

Kód UT WoS kapitoly

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