Antiapoptotic activity of synthetic and natural peptides.

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389030%3A_____%2F03%3A56033067" target="_blank" >RIV/61389030:_____/03:56033067 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Antiapoptotic activity of synthetic and natural peptides.

Popis výsledku v původním jazyce

Our previous studies have shown that peptide mixtures separated from protein digests, as well as individual synthetic peptides are capable of significantly delaying the onset of apoptosis that occurs spontaneously at the decline phase of cell cultures (Franek et al., Biotechnol. Prog.18:155 (2002), Biotechnol. Prog.19:169 (2003)). The characteristic feature of the action of small peptides (two to six amino acid residues) on hybridoma, cultures was the millimolar concentration range needed to achieve significanFchanges of culture parameters. The observed favourable effects of peptides could not be explained by improvement of cell nutrition, because mixtures of free amino acids, constituting the peptides, did not exert comparable effects. The variety ofpeptides tested for their anti-apoptotic activity in mouse hybridoma cultures was now extended to peptides containing non-coded amino acids and D-amino acids. The apoptotic index Al (i.e. apoptotic cells / total cells) in control cultures

Název v anglickém jazyce

Antiapoptotic activity of synthetic and natural peptides.

Popis výsledku anglicky

Our previous studies have shown that peptide mixtures separated from protein digests, as well as individual synthetic peptides are capable of significantly delaying the onset of apoptosis that occurs spontaneously at the decline phase of cell cultures (Franek et al., Biotechnol. Prog.18:155 (2002), Biotechnol. Prog.19:169 (2003)). The characteristic feature of the action of small peptides (two to six amino acid residues) on hybridoma, cultures was the millimolar concentration range needed to achieve significanFchanges of culture parameters. The observed favourable effects of peptides could not be explained by improvement of cell nutrition, because mixtures of free amino acids, constituting the peptides, did not exert comparable effects. The variety ofpeptides tested for their anti-apoptotic activity in mouse hybridoma cultures was now extended to peptides containing non-coded amino acids and D-amino acids. The apoptotic index Al (i.e. apoptotic cells / total cells) in control cultures

Druh

D - Stať ve sborníku

CEP obor

CE - Biochemie

OECD FORD obor

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Projekt

<a href="/cs/project/GA203%2F01%2F0083" target="_blank" >GA203/01/0083: Vztah mezi strukturou a aktivitou regulátorů růstu rostlin s brassinolidní aktivitou</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2003

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

11th Euroconference on Apoptosis 'Cell death under the three towers'.

ISBN

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ISSN

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e-ISSN

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Počet stran výsledku

1

Strana od-do

33

Název nakladatele

European Cell Death Organisation

Místo vydání

N/A

Místo konání akce

Ghent [BE]

Datum konání akce

25. 10. 2003

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

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