Genomic imprinting mediates dosage compensation in a young plant XY system

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389030%3A_____%2F18%3A00495629" target="_blank" >RIV/61389030:_____/18:00495629 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68081707:_____/18:00495090

Výsledek na webu

<a href="http://dx.doi.org/10.1038/s41477-018-0221-y" target="_blank" >http://dx.doi.org/10.1038/s41477-018-0221-y</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/s41477-018-0221-y" target="_blank" >10.1038/s41477-018-0221-y</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Genomic imprinting mediates dosage compensation in a young plant XY system

Popis výsledku v původním jazyce

Sex chromosomes have repeatedly evolved from a pair of autosomes. Consequently, X and Y chromosomes initially have similar gene content, but ongoing Y degeneration leads to reduced expression and eventual loss of Y genes(1). The resulting imbalance in gene expression between Y genes and the rest of the genome is expected to reduce male fitness, especially when protein networks have components from both autosomes and sex chromosomes. A diverse set of dosage compensating mechanisms that alleviates these negative effects has been described in animals(2-4). However, the early steps in the evolution of dosage compensation remain unknown, and dosage compensation is poorly understood in plants(5). Here, we describe a dosage compensation mechanism in the evolutionarily young XY sex determination system of the plant Silene latifolia. Genomic imprinting results in higher expression from the maternal X chromosome in both males and females. This compensates for reduced Y expression in males, but results in X overexpression in females and may be detrimental. It could represent a transient early stage in the evolution of dosage compensation. Our finding has striking resemblance to the first stage proposed by Ohno(6) for the evolution of X inactivation in mammals.

Název v anglickém jazyce

Genomic imprinting mediates dosage compensation in a young plant XY system

Popis výsledku anglicky

Sex chromosomes have repeatedly evolved from a pair of autosomes. Consequently, X and Y chromosomes initially have similar gene content, but ongoing Y degeneration leads to reduced expression and eventual loss of Y genes(1). The resulting imbalance in gene expression between Y genes and the rest of the genome is expected to reduce male fitness, especially when protein networks have components from both autosomes and sex chromosomes. A diverse set of dosage compensating mechanisms that alleviates these negative effects has been described in animals(2-4). However, the early steps in the evolution of dosage compensation remain unknown, and dosage compensation is poorly understood in plants(5). Here, we describe a dosage compensation mechanism in the evolutionarily young XY sex determination system of the plant Silene latifolia. Genomic imprinting results in higher expression from the maternal X chromosome in both males and females. This compensates for reduced Y expression in males, but results in X overexpression in females and may be detrimental. It could represent a transient early stage in the evolution of dosage compensation. Our finding has striking resemblance to the first stage proposed by Ohno(6) for the evolution of X inactivation in mammals.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10611 - Plant sciences, botany

Projekt

<a href="/cs/project/GA16-08698S" target="_blank" >GA16-08698S: Původ a evoluce pohlavních chromozomů u dvoudomé rostliny Rumex acetosa</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Nature Plants

ISSN

2055-026X

e-ISSN

—

Svazek periodika

4

Číslo periodika v rámci svazku

9

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

4

Strana od-do

677-680

Kód UT WoS článku

000446639100018

EID výsledku v databázi Scopus

2-s2.0-85052331627