Exploring the anti-acne potential of Impepho (Helichrysum odoratissimum) to combat Cutibacterium acnes virulence.
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389030%3A_____%2F20%3A00521469" target="_blank" >RIV/61389030:_____/20:00521469 - isvavai.cz</a>
Výsledek na webu
<a href="https://www.frontiersin.org/articles/10.3389/fphar.2019.01559/abstract" target="_blank" >https://www.frontiersin.org/articles/10.3389/fphar.2019.01559/abstract</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3389/fphar.2019.01559" target="_blank" >10.3389/fphar.2019.01559</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Exploring the anti-acne potential of Impepho (Helichrysum odoratissimum) to combat Cutibacterium acnes virulence.
Popis výsledku v původním jazyce
The Gram-positive bacterium Cutibacterium acnes (previously Propionibacterium acnes), plays an important role in the pathogenesis and progression of the dermatological skin disorder acne vulgaris. The methanolic extract of Helichrysum odoratissimum (HO-MeOH) was investigated for its ability to target bacterial growth and pathogenic virulence factors associated with acne progression. The GC-MS analysis of HO-MeOH identified α-humulene, α-curcumene and carophyllene as major constituents, which correlated with previous reports. The HO-MeOH extract exhibited potent antimicrobial activity against C. acnes (ATCC 6919) with an MIC of 7.81 µg/ml. It enhanced the antimicrobial activity of benzoyl peroxide (BPO). The extract showed high specificity against C. acnes cell aggregation at sub-inhibitory concentrations, preventing biofilm formation. Mature C. acnes biofilms were disrupted at a sub-inhibitory concentration of 3.91 µg/ml.
Název v anglickém jazyce
Exploring the anti-acne potential of Impepho (Helichrysum odoratissimum) to combat Cutibacterium acnes virulence.
Popis výsledku anglicky
The Gram-positive bacterium Cutibacterium acnes (previously Propionibacterium acnes), plays an important role in the pathogenesis and progression of the dermatological skin disorder acne vulgaris. The methanolic extract of Helichrysum odoratissimum (HO-MeOH) was investigated for its ability to target bacterial growth and pathogenic virulence factors associated with acne progression. The GC-MS analysis of HO-MeOH identified α-humulene, α-curcumene and carophyllene as major constituents, which correlated with previous reports. The HO-MeOH extract exhibited potent antimicrobial activity against C. acnes (ATCC 6919) with an MIC of 7.81 µg/ml. It enhanced the antimicrobial activity of benzoyl peroxide (BPO). The extract showed high specificity against C. acnes cell aggregation at sub-inhibitory concentrations, preventing biofilm formation. Mature C. acnes biofilms were disrupted at a sub-inhibitory concentration of 3.91 µg/ml.
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
30405 - Medical biotechnology related ethics
Návaznosti výsledku
Projekt
—
Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2020
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Frontiers in Pharmacology
ISSN
1663-9812
e-ISSN
—
Svazek periodika
10
Číslo periodika v rámci svazku
30 January
Stát vydavatele periodika
CH - Švýcarská konfederace
Počet stran výsledku
21
Strana od-do
1559
Kód UT WoS článku
000515382900001
EID výsledku v databázi Scopus
2-s2.0-85079419784