Haem Polymerization Inhibitory Activity and Cytotoxicity of Six Medicinal Plants Used in Cameroon for the Management of Malaria

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389030%3A_____%2F22%3A00565619" target="_blank" >RIV/61389030:_____/22:00565619 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61989592:15310/22:73616995

Výsledek na webu

<a href="https://doi.org/10.23893/1307-2080.APS.6016" target="_blank" >https://doi.org/10.23893/1307-2080.APS.6016</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.23893/1307-2080.APS.6016" target="_blank" >10.23893/1307-2080.APS.6016</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Haem Polymerization Inhibitory Activity and Cytotoxicity of Six Medicinal Plants Used in Cameroon for the Management of Malaria

Popis výsledku v původním jazyce

Malaria was successfully treated with both natural and synthetic products. However, recent progress in battling malaria has stalled due to drug resistance. Therefore, the search of novel antimalarials capable of reversing or evading resistance is much needed and this could be achieved through ethnomedicinal approaches. Six medicinal plants were screened for their antimalarial activity using the β-hematin inhibition (BHI) assay and their effect on the proliferation of three cancer cell lines (A549, MCF7 and PC3) was assessed by the MTT assay. Amongst the twenty-seven extracts screened, Pseudospondias microcarpa bark showed significant BHI activities with IC50 values of 2.5 ± 0.1 and 4.0 ± 0.2 µg/mL for DCM and MeOH extracts, respectively, while having no cytotoxic effect on A549, MCF7 and PC3. The current results support the ethnopharmacological use of P. microcarpa in the treatment of malaria, and it could constitute a useful source of potent antimalarial compounds.

Název v anglickém jazyce

Haem Polymerization Inhibitory Activity and Cytotoxicity of Six Medicinal Plants Used in Cameroon for the Management of Malaria

Popis výsledku anglicky

Malaria was successfully treated with both natural and synthetic products. However, recent progress in battling malaria has stalled due to drug resistance. Therefore, the search of novel antimalarials capable of reversing or evading resistance is much needed and this could be achieved through ethnomedicinal approaches. Six medicinal plants were screened for their antimalarial activity using the β-hematin inhibition (BHI) assay and their effect on the proliferation of three cancer cell lines (A549, MCF7 and PC3) was assessed by the MTT assay. Amongst the twenty-seven extracts screened, Pseudospondias microcarpa bark showed significant BHI activities with IC50 values of 2.5 ± 0.1 and 4.0 ± 0.2 µg/mL for DCM and MeOH extracts, respectively, while having no cytotoxic effect on A549, MCF7 and PC3. The current results support the ethnopharmacological use of P. microcarpa in the treatment of malaria, and it could constitute a useful source of potent antimalarial compounds.

Druh

J_SC - Článek v periodiku v databázi SCOPUS

CEP obor

—

OECD FORD obor

30403 - Technologies involving identifying the functioning of DNA, proteins and enzymes and how they influence the onset of disease and maintenance of well-being (gene-based diagnostics and therapeutic interventions [pharmacogenomics, gene-based therapeutics])

Projekt

<a href="/cs/project/EF16_019%2F0000868" target="_blank" >EF16_019/0000868: Molekulární, buněčný a klinický přístup ke zdravému stárnutí</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Acta Pharmaceutica Sciencia

ISSN

1307-2080

e-ISSN

—

Svazek periodika

60

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

TR - Turecká republika

Počet stran výsledku

12

Strana od-do

235-245

Kód UT WoS článku

—

EID výsledku v databázi Scopus

2-s2.0-85136968124