Small secreted proteins and exocytosis regulators: do they go along?

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389030%3A_____%2F23%3A00571048" target="_blank" >RIV/61389030:_____/23:00571048 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11310/23:10468037

Výsledek na webu

<a href="https://doi.org/10.1080/15592324.2022.2163340" target="_blank" >https://doi.org/10.1080/15592324.2022.2163340</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1080/15592324.2022.2163340" target="_blank" >10.1080/15592324.2022.2163340</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Small secreted proteins and exocytosis regulators: do they go along?

Popis výsledku v původním jazyce

Small secreted proteins play an important role in plant development, as well as in reactions to changes in the environment. In Arabidopsis thaliana, they are predominantly members of highly expanded families, such as the pathogenesis-related (PR) 1-like protein family, whose most studied member PR1 is involved in plant defense responses by a so far unknown mechanism, or Clavata3/Endosperm Surrounding Region (CLE) protein family, whose members’ functions in the development are well described. Our survey of the existing literature for the two families showed a lack of details on their localization, trafficking, and exocytosis. Therefore, in order to uncover the modes of their secretion, we tested the hypothesis that a direct link between the secreted cargoes and the secretion regulators such as Rab GTPases, SNAREs, and exocyst subunits could be established using in silico co-expression and clustering approaches. We employed several independent techniques to uncover that only weak co-expression links could be found for limited numbers of secreted cargoes and regulators. We propose that there might be particular spatio-temporal requirements for PR1 and CLE proteins to be synthesized and secreted, and efforts to experimentally cover these discrepancies should be invested along with functional studies.

Název v anglickém jazyce

Small secreted proteins and exocytosis regulators: do they go along?

Popis výsledku anglicky

Small secreted proteins play an important role in plant development, as well as in reactions to changes in the environment. In Arabidopsis thaliana, they are predominantly members of highly expanded families, such as the pathogenesis-related (PR) 1-like protein family, whose most studied member PR1 is involved in plant defense responses by a so far unknown mechanism, or Clavata3/Endosperm Surrounding Region (CLE) protein family, whose members’ functions in the development are well described. Our survey of the existing literature for the two families showed a lack of details on their localization, trafficking, and exocytosis. Therefore, in order to uncover the modes of their secretion, we tested the hypothesis that a direct link between the secreted cargoes and the secretion regulators such as Rab GTPases, SNAREs, and exocyst subunits could be established using in silico co-expression and clustering approaches. We employed several independent techniques to uncover that only weak co-expression links could be found for limited numbers of secreted cargoes and regulators. We propose that there might be particular spatio-temporal requirements for PR1 and CLE proteins to be synthesized and secreted, and efforts to experimentally cover these discrepancies should be invested along with functional studies.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10608 - Biochemistry and molecular biology

Projekt

<a href="/cs/project/EF16_019%2F0000738" target="_blank" >EF16_019/0000738: Centrum experimentální biologie rostlin</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Plant Signaling & Behavior

ISSN

1559-2316

e-ISSN

1559-2324

Svazek periodika

18

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

7

Strana od-do

2163340

Kód UT WoS článku

000930704300001

EID výsledku v databázi Scopus

2-s2.0-85147834798