Polarity-guided uneven mitotic divisions control brassinosteroid activity in proliferating plant root cells

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389030%3A_____%2F25%3A00619887" target="_blank" >RIV/61389030:_____/25:00619887 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11310/25:10509107

Výsledek na webu

<a href="https://doi.org/10.1016/j.cell.2025.02.011" target="_blank" >https://doi.org/10.1016/j.cell.2025.02.011</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.cell.2025.02.011" target="_blank" >10.1016/j.cell.2025.02.011</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Polarity-guided uneven mitotic divisions control brassinosteroid activity in proliferating plant root cells

Popis výsledku v původním jazyce

Brassinosteroid hormones are positive regulators of plant organ growth, yet their function in proliferating tissues remains unclear. Here, through integrating single-cell RNA sequencing with long-term live-cell imaging of the Arabidopsis root, we reveal that brassinosteroid activity fluctuates throughout the cell cycle, decreasing during mitotic divisions and increasing during the G1 phase. The post-mitotic recovery of brassinosteroid activity is driven by the intrinsic polarity of the mother cell, resulting in one daughter cell with enhanced brassinosteroid signaling, while the other supports brassinosteroid biosynthesis. The coexistence of these distinct daughter cell states during the G1 phase circumvents a negative feedback loop to facilitate brassinosteroid production while signaling increases. Our findings uncover polarity-guided, uneven mitotic divisions in the meristem, which control brassinosteroid hormone activity to ensure optimal root growth.

Název v anglickém jazyce

Polarity-guided uneven mitotic divisions control brassinosteroid activity in proliferating plant root cells

Popis výsledku anglicky

Brassinosteroid hormones are positive regulators of plant organ growth, yet their function in proliferating tissues remains unclear. Here, through integrating single-cell RNA sequencing with long-term live-cell imaging of the Arabidopsis root, we reveal that brassinosteroid activity fluctuates throughout the cell cycle, decreasing during mitotic divisions and increasing during the G1 phase. The post-mitotic recovery of brassinosteroid activity is driven by the intrinsic polarity of the mother cell, resulting in one daughter cell with enhanced brassinosteroid signaling, while the other supports brassinosteroid biosynthesis. The coexistence of these distinct daughter cell states during the G1 phase circumvents a negative feedback loop to facilitate brassinosteroid production while signaling increases. Our findings uncover polarity-guided, uneven mitotic divisions in the meristem, which control brassinosteroid hormone activity to ensure optimal root growth.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10601 - Cell biology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Cell

ISSN

0092-8674

e-ISSN

1097-4172

Svazek periodika

188

Číslo periodika v rámci svazku

8

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

18

Strana od-do

2063-2080

Kód UT WoS článku

001476122000001

EID výsledku v databázi Scopus

2-s2.0-86000636557