Bioactive phytochemicals, pharmacological, and therapeutic potential of Dillenia indica: A comprehensive review of current research

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389030%3A_____%2F25%3A00641552" target="_blank" >RIV/61389030:_____/25:00641552 - isvavai.cz</a>

Výsledek na webu

<a href="https://doi.org/10.1016/j.chmed.2025.09.001" target="_blank" >https://doi.org/10.1016/j.chmed.2025.09.001</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.chmed.2025.09.001" target="_blank" >10.1016/j.chmed.2025.09.001</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Bioactive phytochemicals, pharmacological, and therapeutic potential of Dillenia indica: A comprehensive review of current research

Popis výsledku v původním jazyce

Dillenia indica, commonly known as elephant apple, is a tropical fruit-bearing tree with a rich history of medicinal use in traditional medicine across Southeast Asia and the Indian subcontinent. This review comprehensively examines current research on the pharmacological properties of D. indica, focusing on its diverse bioactive compounds, including flavonoids, tannins, saponins, and triterpenoids, which underpin its key biological activities such as antioxidant, anti-inflammatory, antimicrobial, anticancer, antidiabetic, and hepatoprotective properties. Flavonoids and tannins exhibit potent antioxidant activity, effectively scavenging free radicals and reducing oxidative stress, a mechanism implicated in metabolic disorders, cancer, and neurodegenerative diseases. Additionally, the plant demonstrates considerable anti-inflammatory effects by modulating key inflammatory pathways, including the inhibition of pro-inflammatory cytokines such as tumor necrosis factor-a (TNF-a) and interleukin-6 (IL-6). Saponins and triterpenoids enhance its antimicrobial activity, supporting traditional uses for treating infections. Preclinical studies indicate that D. indica extracts can inhibit cancer cell proliferation and induce apoptosis in various cancer types, including breast, colorectal, and liver cancers. Furthermore, specific formulations may improve the bioavailability and targeted delivery of active constituents, thereby increasing therapeutic efficacy. Despite the promising findings in vitro and in vivo, there is a notable lack of well-designed clinical trials to validate these effects in humans. The plant is generally considered safe when consumed at recommended doses. However, excessive intake may lead to gastrointestinal discomfort and, in rare cases, hepatotoxicity. This review describes the therapeutic potential of D. indica as a natural agent while emphasizing the urgent need for comprehensive clinical trials, particularly those investigating pharmacodynamics profiles, to confirm its efficacy and safety.

Název v anglickém jazyce

Bioactive phytochemicals, pharmacological, and therapeutic potential of Dillenia indica: A comprehensive review of current research

Popis výsledku anglicky

Dillenia indica, commonly known as elephant apple, is a tropical fruit-bearing tree with a rich history of medicinal use in traditional medicine across Southeast Asia and the Indian subcontinent. This review comprehensively examines current research on the pharmacological properties of D. indica, focusing on its diverse bioactive compounds, including flavonoids, tannins, saponins, and triterpenoids, which underpin its key biological activities such as antioxidant, anti-inflammatory, antimicrobial, anticancer, antidiabetic, and hepatoprotective properties. Flavonoids and tannins exhibit potent antioxidant activity, effectively scavenging free radicals and reducing oxidative stress, a mechanism implicated in metabolic disorders, cancer, and neurodegenerative diseases. Additionally, the plant demonstrates considerable anti-inflammatory effects by modulating key inflammatory pathways, including the inhibition of pro-inflammatory cytokines such as tumor necrosis factor-a (TNF-a) and interleukin-6 (IL-6). Saponins and triterpenoids enhance its antimicrobial activity, supporting traditional uses for treating infections. Preclinical studies indicate that D. indica extracts can inhibit cancer cell proliferation and induce apoptosis in various cancer types, including breast, colorectal, and liver cancers. Furthermore, specific formulations may improve the bioavailability and targeted delivery of active constituents, thereby increasing therapeutic efficacy. Despite the promising findings in vitro and in vivo, there is a notable lack of well-designed clinical trials to validate these effects in humans. The plant is generally considered safe when consumed at recommended doses. However, excessive intake may lead to gastrointestinal discomfort and, in rare cases, hepatotoxicity. This review describes the therapeutic potential of D. indica as a natural agent while emphasizing the urgent need for comprehensive clinical trials, particularly those investigating pharmacodynamics profiles, to confirm its efficacy and safety.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30107 - Medicinal chemistry

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Chinese Herbal Medicines

ISSN

1674-6384

e-ISSN

1674-6384

Svazek periodika

17

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

SG - Singapurská republika

Počet stran výsledku

15

Strana od-do

628-642

Kód UT WoS článku

001607398600003

EID výsledku v databázi Scopus

2-s2.0-105015376055