Chronobiological aspects of reoxygenation impact on the heart rhythm disorders in Wistar rat model

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17110%2F11%3AA12013XB" target="_blank" >RIV/61988987:17110/11:A12013XB - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Chronobiological aspects of reoxygenation impact on the heart rhythm disorders in Wistar rat model

Popis výsledku v původním jazyce

The clinical trials unanimously ascribe the increased risk of cardiac events to apneic episodes. The effect of reoxygenation after apneic episode on the development of ventricular arrhythmias have not been studied in detail as a function of the lightdarkcycle (LD cycle). We aimed to study the effect of reoxygenation on ventricular arrhythmia threshold (VAT) with respect to the LD cycle. Experiments were undertaken in female Wistar rats. The results clearly demonstrate the pro-arrhythmogenic effect of apneic episode regardless of the LD cycle. During reoxygenation, anti-arrhythmogenic effect (increase in VAT) was observed in the dark (active) part in contrast to pro-arrhythmogenic effect (decrease in VAT), which was demostrated during the light (nonactive) part of the day. These data suggest that heart rhythm disorders attributed to apneic episode can be attenuated or amplified by subsequent reoxygenation dependent on synchronization to the LD cycle.

Název v anglickém jazyce

Chronobiological aspects of reoxygenation impact on the heart rhythm disorders in Wistar rat model

Popis výsledku anglicky

The clinical trials unanimously ascribe the increased risk of cardiac events to apneic episodes. The effect of reoxygenation after apneic episode on the development of ventricular arrhythmias have not been studied in detail as a function of the lightdarkcycle (LD cycle). We aimed to study the effect of reoxygenation on ventricular arrhythmia threshold (VAT) with respect to the LD cycle. Experiments were undertaken in female Wistar rats. The results clearly demonstrate the pro-arrhythmogenic effect of apneic episode regardless of the LD cycle. During reoxygenation, anti-arrhythmogenic effect (increase in VAT) was observed in the dark (active) part in contrast to pro-arrhythmogenic effect (decrease in VAT), which was demostrated during the light (nonactive) part of the day. These data suggest that heart rhythm disorders attributed to apneic episode can be attenuated or amplified by subsequent reoxygenation dependent on synchronization to the LD cycle.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FA - Kardiovaskulární nemoci včetně kardiochirurgie

OECD FORD obor

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Projekt

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Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Trendsin Comparative Biochem & Physiol

ISSN

0972-4540

e-ISSN

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Svazek periodika

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Číslo periodika v rámci svazku

15

Stát vydavatele periodika

IN - Indická republika

Počet stran výsledku

7

Strana od-do

55-61

Kód UT WoS článku

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EID výsledku v databázi Scopus

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