Cytogenetics in multiple myeloma patients progressing into extramedullary disease

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17110%2F16%3AA1701J66" target="_blank" >RIV/61988987:17110/16:A1701J66 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14110/16:00089123 RIV/65269705:_____/16:00065515 RIV/00843989:_____/16:E0105516

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Cytogenetics in multiple myeloma patients progressing into extramedullary disease

Popis výsledku v původním jazyce

Background: Extramedullary disease in multiple myeloma patients is an uncommon event occurring either at the time of diagnosis, or during disease progression/relapse. This manifestation is frequently associated with poor outcome and resistance to treatment. We evaluated chromosomal alterations of plasma cells of multiple myeloma patients with extramedullary relapse, either in the bone marrow (BM) or at extramedullary sites, and in previous BM collection by interphase fluorescence in situ hybridization. Material and methods: Thirty-one patients [25 BM plasma cells (BMPCs), 18 extramedullary tumor plasma cells], of which 12 had paired samples of BM and extramedullary plasma cells and 14 had previous collection of BM, were investigated for the presence of chromosomal aberrations (CHAs): del(17)(p13), del (13)(q14), 14q32 disruption, t(4; 14)(p16; q32), t(14; 16)(q32; q23), gain(1)(q21), and hyperdiploidy status. Results: Overall, in unrelated samples, t(4; 14) was more prevalent in extramedullary plasma cells, and hyperdiploidy was more frequent in BMPCs. In paired samples, there was a higher frequency of del(13) (q14) and 14q32 disruption in BMPCs. Frequency of all studied CHAs was higher in BMPCs of extramedullary patients than in their previous sample collection. Conclusion: These data show that plasma cells harbor more aberrations during their transformation into extramedullary form.

Název v anglickém jazyce

Cytogenetics in multiple myeloma patients progressing into extramedullary disease

Popis výsledku anglicky

Background: Extramedullary disease in multiple myeloma patients is an uncommon event occurring either at the time of diagnosis, or during disease progression/relapse. This manifestation is frequently associated with poor outcome and resistance to treatment. We evaluated chromosomal alterations of plasma cells of multiple myeloma patients with extramedullary relapse, either in the bone marrow (BM) or at extramedullary sites, and in previous BM collection by interphase fluorescence in situ hybridization. Material and methods: Thirty-one patients [25 BM plasma cells (BMPCs), 18 extramedullary tumor plasma cells], of which 12 had paired samples of BM and extramedullary plasma cells and 14 had previous collection of BM, were investigated for the presence of chromosomal aberrations (CHAs): del(17)(p13), del (13)(q14), 14q32 disruption, t(4; 14)(p16; q32), t(14; 16)(q32; q23), gain(1)(q21), and hyperdiploidy status. Results: Overall, in unrelated samples, t(4; 14) was more prevalent in extramedullary plasma cells, and hyperdiploidy was more frequent in BMPCs. In paired samples, there was a higher frequency of del(13) (q14) and 14q32 disruption in BMPCs. Frequency of all studied CHAs was higher in BMPCs of extramedullary patients than in their previous sample collection. Conclusion: These data show that plasma cells harbor more aberrations during their transformation into extramedullary form.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FD - Onkologie a hematologie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

EUR J HAEMATOL

ISSN

0902-4441

e-ISSN

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Svazek periodika

97

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

8

Strana od-do

93-100

Kód UT WoS článku

000378432900015

EID výsledku v databázi Scopus

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