Topiramate induced metabolic acidosis and kidney stones - a case study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17110%2F17%3AA1801NF6" target="_blank" >RIV/61988987:17110/17:A1801NF6 - isvavai.cz</a>

Výsledek na webu

<a href="http://www.biochemia-medica.com/2017/2/404" target="_blank" >http://www.biochemia-medica.com/2017/2/404</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.11613/BM.2017.042" target="_blank" >10.11613/BM.2017.042</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Topiramate induced metabolic acidosis and kidney stones - a case study

Popis výsledku v původním jazyce

Introduction: The aim of this study is to present a case of 44 years old woman with topiramate induced metabolic acidosis and kidney stones.Materials and methods: The laboratory features of topiramate caused renal tubular acidosis in blood and urine during topiramate treatment, with correction of metabolic acidosis by potassium citrate, and after topiramate withdrawal are presented. Differential diagnosis of all possible causes of metabolic acidosis is discussed.Results: The results revealed negative base excess in extracellular fluid of - 9.2 mmol/L, low serum HCO3- concentration (18.6 mmol/L), trend to alkaline urine (pH 6.39) and low urine citrate concentration (0.3 mmol/24h). After topiramate withdrawal, all parameters of the internal environment normalized.Conclusions: This study has shown that long-term topiramate administration could induce metabolic acidosis and consequently urholithiasis. Thus, we could recommend testing blood acid base balance, urinary pH and citrates in patients taking topiramate and suffering from kidney stones.

Název v anglickém jazyce

Topiramate induced metabolic acidosis and kidney stones - a case study

Popis výsledku anglicky

Introduction: The aim of this study is to present a case of 44 years old woman with topiramate induced metabolic acidosis and kidney stones.Materials and methods: The laboratory features of topiramate caused renal tubular acidosis in blood and urine during topiramate treatment, with correction of metabolic acidosis by potassium citrate, and after topiramate withdrawal are presented. Differential diagnosis of all possible causes of metabolic acidosis is discussed.Results: The results revealed negative base excess in extracellular fluid of - 9.2 mmol/L, low serum HCO3- concentration (18.6 mmol/L), trend to alkaline urine (pH 6.39) and low urine citrate concentration (0.3 mmol/24h). After topiramate withdrawal, all parameters of the internal environment normalized.Conclusions: This study has shown that long-term topiramate administration could induce metabolic acidosis and consequently urholithiasis. Thus, we could recommend testing blood acid base balance, urinary pH and citrates in patients taking topiramate and suffering from kidney stones.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

20602 - Medical laboratory technology (including laboratory samples analysis; diagnostic technologies) (Biomaterials to be 2.9 [physical characteristics of living material as related to medical implants, devices, sensors])

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

BIOCHEMIA MEDICA

ISSN

1330-0962

e-ISSN

—

Svazek periodika

27

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

HR - Chorvatská republika

Počet stran výsledku

7

Strana od-do

404-410

Kód UT WoS článku

000404505700017

EID výsledku v databázi Scopus

2-s2.0-85020621263