ROLE OF VWF, FVIII AND ADAMTS13 IN THE OUTCOME OF ACUTE STROKE PATIENTS TREATED WITH MECHANICAL THROMBECTOMY - PILOT STUDY

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17110%2F17%3AA22020TA" target="_blank" >RIV/61988987:17110/17:A22020TA - isvavai.cz</a>

Výsledek na webu

<a href="https://journals.sagepub.com/doi/full/10.1177/1747493017703913" target="_blank" >https://journals.sagepub.com/doi/full/10.1177/1747493017703913</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

ROLE OF VWF, FVIII AND ADAMTS13 IN THE OUTCOME OF ACUTE STROKE PATIENTS TREATED WITH MECHANICAL THROMBECTOMY - PILOT STUDY

Popis výsledku v původním jazyce

Introduction: VWF and f VIII are determinants of thrombi creation. ADAMTS13 influence thrombus dissolution. Objectives: Higher levels of Von Willebrand Factor (vWF), factor VIII (f VIII) and low Von Willebrand factor-cleaving protease (ADAMTS13) enzyme are factors that may influence the outcome in stroke patients treated with mechanical thrombectomy. Methods: 50 patients (27 males, mean age 68 ± 11.0 years) with acute ischemic stroke and occlusion of middle cerebral artery (MCA), internal carotid artery (ICA) or basilar artery (BA) treated with mechanical thrombectomy were enrolled to the study between August and December 2016. Baseline blood levels of VWF, fVIII, ADAMTS13 were correlated with procedure length, recanalization success, National Institutes of Health Stroke Scale (NIHSS) at baseline and day 7, and 3-month outcome in modified Rankin Scale (mRS). Results: Significant correlations were found between higher serum levels of vWF and fVIII versus low levels of ADAMTS13 in patients with severe strokes (baseline NIHSS > 15) and in patients with worse clinical outcome (NIHSS ≥ 10 at day 7 and mRS ≥ 3 at day 90). No significant correlations have been found between factors' levels and procedure duration or recanalization success. Conclusion: Levels of platelets adhesion factors VWF, fVIII and ADAMTS13 are in correlation with stroke severity and stroke patients' outcome after thrombectomy.

Název v anglickém jazyce

ROLE OF VWF, FVIII AND ADAMTS13 IN THE OUTCOME OF ACUTE STROKE PATIENTS TREATED WITH MECHANICAL THROMBECTOMY - PILOT STUDY

Popis výsledku anglicky

Introduction: VWF and f VIII are determinants of thrombi creation. ADAMTS13 influence thrombus dissolution. Objectives: Higher levels of Von Willebrand Factor (vWF), factor VIII (f VIII) and low Von Willebrand factor-cleaving protease (ADAMTS13) enzyme are factors that may influence the outcome in stroke patients treated with mechanical thrombectomy. Methods: 50 patients (27 males, mean age 68 ± 11.0 years) with acute ischemic stroke and occlusion of middle cerebral artery (MCA), internal carotid artery (ICA) or basilar artery (BA) treated with mechanical thrombectomy were enrolled to the study between August and December 2016. Baseline blood levels of VWF, fVIII, ADAMTS13 were correlated with procedure length, recanalization success, National Institutes of Health Stroke Scale (NIHSS) at baseline and day 7, and 3-month outcome in modified Rankin Scale (mRS). Results: Significant correlations were found between higher serum levels of vWF and fVIII versus low levels of ADAMTS13 in patients with severe strokes (baseline NIHSS > 15) and in patients with worse clinical outcome (NIHSS ≥ 10 at day 7 and mRS ≥ 3 at day 90). No significant correlations have been found between factors' levels and procedure duration or recanalization success. Conclusion: Levels of platelets adhesion factors VWF, fVIII and ADAMTS13 are in correlation with stroke severity and stroke patients' outcome after thrombectomy.

Druh

D - Stať ve sborníku

CEP obor

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OECD FORD obor

30210 - Clinical neurology

Projekt

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Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

INTERNATIONAL JOURNAL OF STROKE

ISBN

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ISSN

1747-4930

e-ISSN

1747-4949

Počet stran výsledku

1

Strana od-do

45-45

Název nakladatele

SAGE PUBLICATIONS LTD, 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND

Místo vydání

LONDON EC1Y 1SP, ENGLAND

Místo konání akce

London

Datum konání akce

1. 1. 2017

Typ akce podle státní příslušnosti

EUR - Evropská akce

Kód UT WoS článku

000401515800135