Free light chains in the cerebrospinal fluid. Do we still need oligoclonal IgG?

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17110%2F18%3AA20020PP" target="_blank" >RIV/61988987:17110/18:A20020PP - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00843989:_____/18:E0107126

Výsledek na webu

<a href="https://www.degruyter.com/downloadpdf/j/cclm.2018.56.issue-7/cclm-2018-0096/cclm-2018-0096.pdf" target="_blank" >https://www.degruyter.com/downloadpdf/j/cclm.2018.56.issue-7/cclm-2018-0096/cclm-2018-0096.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1515/cclm-2018-0096" target="_blank" >10.1515/cclm-2018-0096</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Free light chains in the cerebrospinal fluid. Do we still need oligoclonal IgG?

Popis výsledku v původním jazyce

The diagnosis of multiple sclerosis (MS) is based on the demonstration of dissemination in space (DIS), i.e. involvement of different areas of the central nervous system (CNS), and dissemination in time (DIT), i.e. the occurrence of at least two relapses or, in the case of primary progressive MS, disability progression for at least 1 year. Magnetic resonance imaging (MRI) is the most important paraclinical test in patients with suspected MS that can demonstrate both DIS and DIT (i.e. simultaneous appearance of new and old lesions or appearance of new lesions over time). However, MRI findings lack pathological specificity, and an increasing proportion of MS patients is diagnosed after the first clinical episode suggestive of a demyelinating disease where the criterion of DIT might not be met. Demonstration of an inflammatory nature of the disease by means of CSF analysis, namely the presence of intrathecal humoral immune response, has been used for decades to support MS diagnosis, despite the fact that the importance of CSF analysis was de-emphasised in successive revisions of the McDonald MS diagnostic criteria [1]. The latest revision of these criteria, published ahead of print on December 21, 2017, revived the role of CSF analysis by stating that the presence of 2 or more oligoclonal bands (OCB) in the CSF absent from serum can substitute for the DIT criterion and thus enable determining the diagnosis of MS in patients with the first episode suggestive of a demyelinating disease (the so-called clinically isolated syndrome, CIS) if the DIS criteria are met [2].

Název v anglickém jazyce

Free light chains in the cerebrospinal fluid. Do we still need oligoclonal IgG?

Popis výsledku anglicky

The diagnosis of multiple sclerosis (MS) is based on the demonstration of dissemination in space (DIS), i.e. involvement of different areas of the central nervous system (CNS), and dissemination in time (DIT), i.e. the occurrence of at least two relapses or, in the case of primary progressive MS, disability progression for at least 1 year. Magnetic resonance imaging (MRI) is the most important paraclinical test in patients with suspected MS that can demonstrate both DIS and DIT (i.e. simultaneous appearance of new and old lesions or appearance of new lesions over time). However, MRI findings lack pathological specificity, and an increasing proportion of MS patients is diagnosed after the first clinical episode suggestive of a demyelinating disease where the criterion of DIT might not be met. Demonstration of an inflammatory nature of the disease by means of CSF analysis, namely the presence of intrathecal humoral immune response, has been used for decades to support MS diagnosis, despite the fact that the importance of CSF analysis was de-emphasised in successive revisions of the McDonald MS diagnostic criteria [1]. The latest revision of these criteria, published ahead of print on December 21, 2017, revived the role of CSF analysis by stating that the presence of 2 or more oligoclonal bands (OCB) in the CSF absent from serum can substitute for the DIT criterion and thus enable determining the diagnosis of MS in patients with the first episode suggestive of a demyelinating disease (the so-called clinically isolated syndrome, CIS) if the DIS criteria are met [2].

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10608 - Biochemistry and molecular biology

Projekt

—

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

CLINICAL CHEMISTRY AND LABORATORY MEDICINE

ISSN

1434-6621

e-ISSN

1437-4331

Svazek periodika

56

Číslo periodika v rámci svazku

7

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

4

Strana od-do

1011-1014

Kód UT WoS článku

000433906000009

EID výsledku v databázi Scopus

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