Intraplaque hemorrhage in symptomatic and asymptomatic progressive carotid artery stenosis-a pilot study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17110%2F18%3AA20020PX" target="_blank" >RIV/61988987:17110/18:A20020PX - isvavai.cz</a>

Výsledek na webu

—

DOI - Digital Object Identifier

—

Jazyk výsledku

angličtina

Název v původním jazyce

Intraplaque hemorrhage in symptomatic and asymptomatic progressive carotid artery stenosis-a pilot study

Popis výsledku v původním jazyce

Background and aims Intraplaque hemorrhage (IPH) belongs to potential mechanisms of unstable plaque development. Study aims to compare the IPH occurrence in patients with asymptomatic stable (ASS), asymptomatic progressive (APS) and symptomatic (SS) carotid artery stenosis ˃50%. Methods Serial duplex ultrasound (DUS) in a 6-month period and magnetic resonance imaging (MRI) using axial 3DT1w sequence were used for IPH detection in patients with carotid stenosis. Stenoses in patients with ipsilateral stroke/transient ischemic attack within previous 4 weeks or acute ischemic lesion on diffusion-weighted MRI were evaluated as symptomatic. Stenoses with progression of ˃10% since last DUS examination were evaluated as progressive. Echolucent part of atherosclerotic plaque ˃8 mm2 on DUS and hyperintensity on 3DT1w-MRI were evaluated as IPH. Differences in IPH occurrence between ASS, APS and SS patients were statistically evaluated. Results Totally 32 patients (18 males, mean age 71.3±7.7 years) were enrolled during 18 months; 5 patients with ASS, 18 with APS and 9 with SS. MRI examination was not performed in 3 ASS and 1 SS patient. IPH was detected using DUS/MRI in 1 (20%)/2 (40%) of ASS patients, 9 (50%)/8 (53%) of APS patients, and 5 (56%)/4 (50%) of SS patients (p˃0.05 in all cases). IPH on both DUS and MRI were detected in none of ASS patients, 5 (28%) APS patients and 3 (33%) SS patients (p˃0.05 in all cases). Conclusion No significant difference in IPH occurrence was found between ASS, APS and SS patients. Totally 200 patients will be enrolled to the ongoing study.

Název v anglickém jazyce

Intraplaque hemorrhage in symptomatic and asymptomatic progressive carotid artery stenosis-a pilot study

Popis výsledku anglicky

Background and aims Intraplaque hemorrhage (IPH) belongs to potential mechanisms of unstable plaque development. Study aims to compare the IPH occurrence in patients with asymptomatic stable (ASS), asymptomatic progressive (APS) and symptomatic (SS) carotid artery stenosis ˃50%. Methods Serial duplex ultrasound (DUS) in a 6-month period and magnetic resonance imaging (MRI) using axial 3DT1w sequence were used for IPH detection in patients with carotid stenosis. Stenoses in patients with ipsilateral stroke/transient ischemic attack within previous 4 weeks or acute ischemic lesion on diffusion-weighted MRI were evaluated as symptomatic. Stenoses with progression of ˃10% since last DUS examination were evaluated as progressive. Echolucent part of atherosclerotic plaque ˃8 mm2 on DUS and hyperintensity on 3DT1w-MRI were evaluated as IPH. Differences in IPH occurrence between ASS, APS and SS patients were statistically evaluated. Results Totally 32 patients (18 males, mean age 71.3±7.7 years) were enrolled during 18 months; 5 patients with ASS, 18 with APS and 9 with SS. MRI examination was not performed in 3 ASS and 1 SS patient. IPH was detected using DUS/MRI in 1 (20%)/2 (40%) of ASS patients, 9 (50%)/8 (53%) of APS patients, and 5 (56%)/4 (50%) of SS patients (p˃0.05 in all cases). IPH on both DUS and MRI were detected in none of ASS patients, 5 (28%) APS patients and 3 (33%) SS patients (p˃0.05 in all cases). Conclusion No significant difference in IPH occurrence was found between ASS, APS and SS patients. Totally 200 patients will be enrolled to the ongoing study.

Druh

D - Stať ve sborníku

CEP obor

—

OECD FORD obor

30210 - Clinical neurology

Projekt

—

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

EUROPEAN JOURNAL OF NEUROLOGY

ISBN

—

ISSN

1351-5101

e-ISSN

1468-1331

Počet stran výsledku

1

Strana od-do

156-156

Název nakladatele

WILEY, 111 RIVER ST, HOBOKEN 07030-5774, NJ USA

Místo vydání

HOBOKEN 07030-5774, NJ USA

Místo konání akce

Lisabon Portugalsko

Datum konání akce

1. 1. 2018

Typ akce podle státní příslušnosti

EUR - Evropská akce

Kód UT WoS článku

000435272001113