VAGAL MODULATION AND COGNITIVE DECLINE OVER 10 YEARS: THE WHITEHALL II COHORT STUDY

Kód výsledku v IS VaVaI

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Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

VAGAL MODULATION AND COGNITIVE DECLINE OVER 10 YEARS: THE WHITEHALL II COHORT STUDY

Popis výsledku v původním jazyce

Dysfunction of autonomic nervous system may contribute to neuronal damage. The research in this area is limited. We prospectively investigated whether decreased vagal modulation, indexed by high frequency heart rate variability (HF-HRV), in midlife predicts subsequent cognitive decline. Method: Data from the fifth (1997-1999), seventh (2002-2004) and ninth (2007-2009) phases of the UK Whitehall II longitudinal population-based cohort study were analysed. The sample size was 4471 (1247 women). Cognitive function measures included memory, reasoning, vocabulary, executive function and global cognition. Heart rate variability was obtained during 5 min of supine rest. The values of HF-HRV at phase 5 were divided into quartiles. Random mixed models were applied. Results: Over a 10 year period there was significantly greater decline in vocabulary (β=-0.15; p=0.001), reasoning, (β=-0.11; p=0.007), executive function (β=-0.09; p=0.033) and global cognition (β=-0.07; p=0.027 ) among men with baseline HF-HRV in the lowest quartile than others. Statistically insignificant associations were found in women. All models were adjusted for age, ethnicity and education. Further adjustments for known confounders including sociodemographic and lifestyle factors, cardiometabolic conditions and medication did not change the predictive effect of HRV on cognitive decline. Conclusion: Findings support an etiological role of the autonomic nervous system in cognitive decline.

Název v anglickém jazyce

VAGAL MODULATION AND COGNITIVE DECLINE OVER 10 YEARS: THE WHITEHALL II COHORT STUDY

Popis výsledku anglicky

Dysfunction of autonomic nervous system may contribute to neuronal damage. The research in this area is limited. We prospectively investigated whether decreased vagal modulation, indexed by high frequency heart rate variability (HF-HRV), in midlife predicts subsequent cognitive decline. Method: Data from the fifth (1997-1999), seventh (2002-2004) and ninth (2007-2009) phases of the UK Whitehall II longitudinal population-based cohort study were analysed. The sample size was 4471 (1247 women). Cognitive function measures included memory, reasoning, vocabulary, executive function and global cognition. Heart rate variability was obtained during 5 min of supine rest. The values of HF-HRV at phase 5 were divided into quartiles. Random mixed models were applied. Results: Over a 10 year period there was significantly greater decline in vocabulary (β=-0.15; p=0.001), reasoning, (β=-0.11; p=0.007), executive function (β=-0.09; p=0.033) and global cognition (β=-0.07; p=0.027 ) among men with baseline HF-HRV in the lowest quartile than others. Statistically insignificant associations were found in women. All models were adjusted for age, ethnicity and education. Further adjustments for known confounders including sociodemographic and lifestyle factors, cardiometabolic conditions and medication did not change the predictive effect of HRV on cognitive decline. Conclusion: Findings support an etiological role of the autonomic nervous system in cognitive decline.

Druh

D - Stať ve sborníku

CEP obor

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OECD FORD obor

30302 - Epidemiology

Projekt

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Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

PSYCHOSOMATIC MEDICINE

ISBN

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ISSN

0033-3174

e-ISSN

1534-7796

Počet stran výsledku

1

Strana od-do

12-12

Název nakladatele

LIPPINCOTT WILLIAMS & WILKINS, TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA

Místo vydání

PHILADELPHIA, PA 19103 USA

Místo konání akce

Louisville, KY

Datum konání akce

1. 1. 2018

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

000436027400027