Valproic acid concentrations in nursing mothers, mature milk, and breastfed infants in monotherapy and combination therapy

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17110%2F19%3AA200231U" target="_blank" >RIV/61988987:17110/19:A200231U - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00843989:_____/19:E0107796

Výsledek na webu

<a href="https://reader.elsevier.com/reader/sd/pii/S1525505019301210?token=0DD9E9B0C859B3FC771D0F37A2864B6A0DD74EB2E96B0842B3BB4B3CA4A82C232E88AD133C454BE9637EF83A1790651E" target="_blank" >https://reader.elsevier.com/reader/sd/pii/S1525505019301210?token=0DD9E9B0C859B3FC771D0F37A2864B6A0DD74EB2E96B0842B3BB4B3CA4A82C232E88AD133C454BE9637EF83A1790651E</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.yebeh.2019.04.002" target="_blank" >10.1016/j.yebeh.2019.04.002</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Valproic acid concentrations in nursing mothers, mature milk, and breastfed infants in monotherapy and combination therapy

Popis výsledku v původním jazyce

Valproic acid (VPA) is currently one of the four most often prescribed antiepileptic drugs (AEDs) in pregnancy. However, only a small number of studies have measured suckling infant serum levels of the drug. We studied the transport of VPA from breastfeeding mothers to the mature milk and breastfed infants and the influence of comedication with enzyme-inducing AEDs. The data of 30 nursing women treated by VPA were analyzed retro-spectively. Mature milk, maternal, and infant serum levels were collected between the 6th and 32nd postnatal day and measured by gas chromatography during the years 1996-2017. Valproic acid levels varied from 5.4 to 69.0 mg/L (mean: 39.0 +/- 16.1 mg/L) in the maternal serum, from <1.0 to 16.7 mg/L (mean: 1.6 +/- 3.9 mg/L) in the milk, and from <1.0 to 17.5 mg/L (mean: 4.2 = 4.3 mg/L) in the infant serum. The milk/maternal serum level ratio ranged from <0.03 to 0.25 (mean: 0.03 +/- 0.06) and the infant/maternal serum level ratio from <0.03 to 0.61 (mean: 0.11 +/- 0.13). Sixty-seven percent of milk and 33% of infant VPA concentrations were below the limit of quantification. No correlations were observed between maternal serum and milk levels or between maternal and infant serum levels. In conclusion, none of the milk or infant serum VPA levels reached the lower limit of the reference range used for the general population with epilepsy, so the degree of VPA exposure in breastfed infants is less than during gestation. Nevertheless, if signs of potential adverse reactions manifest, infant serum concentrations should be measured. Keywords: Valproic add Breastfeeding Milk Infant Therapeutic drug monitoring (C) 2019 Elsevier Inc. All rights reserved.

Název v anglickém jazyce

Valproic acid concentrations in nursing mothers, mature milk, and breastfed infants in monotherapy and combination therapy

Popis výsledku anglicky

Valproic acid (VPA) is currently one of the four most often prescribed antiepileptic drugs (AEDs) in pregnancy. However, only a small number of studies have measured suckling infant serum levels of the drug. We studied the transport of VPA from breastfeeding mothers to the mature milk and breastfed infants and the influence of comedication with enzyme-inducing AEDs. The data of 30 nursing women treated by VPA were analyzed retro-spectively. Mature milk, maternal, and infant serum levels were collected between the 6th and 32nd postnatal day and measured by gas chromatography during the years 1996-2017. Valproic acid levels varied from 5.4 to 69.0 mg/L (mean: 39.0 +/- 16.1 mg/L) in the maternal serum, from <1.0 to 16.7 mg/L (mean: 1.6 +/- 3.9 mg/L) in the milk, and from <1.0 to 17.5 mg/L (mean: 4.2 = 4.3 mg/L) in the infant serum. The milk/maternal serum level ratio ranged from <0.03 to 0.25 (mean: 0.03 +/- 0.06) and the infant/maternal serum level ratio from <0.03 to 0.61 (mean: 0.11 +/- 0.13). Sixty-seven percent of milk and 33% of infant VPA concentrations were below the limit of quantification. No correlations were observed between maternal serum and milk levels or between maternal and infant serum levels. In conclusion, none of the milk or infant serum VPA levels reached the lower limit of the reference range used for the general population with epilepsy, so the degree of VPA exposure in breastfed infants is less than during gestation. Nevertheless, if signs of potential adverse reactions manifest, infant serum concentrations should be measured. Keywords: Valproic add Breastfeeding Milk Infant Therapeutic drug monitoring (C) 2019 Elsevier Inc. All rights reserved.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10614 - Behavioral sciences biology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

EPILEPSY & BEHAVIOR

ISSN

1525-5050

e-ISSN

1525-5069

Svazek periodika

95

Číslo periodika v rámci svazku

červen

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

5

Strana od-do

112-116

Kód UT WoS článku

000469418500018

EID výsledku v databázi Scopus

2-s2.0-85064667607