Pharmacological strategies for the management of comorbid depression and schizophrenia

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17110%2F20%3AA21028AG" target="_blank" >RIV/61988987:17110/20:A21028AG - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14740/20:00115688 RIV/65269705:_____/20:00072698 RIV/00843989:_____/20:E0108379

Výsledek na webu

<a href="https://www.tandfonline.com/doi/full/10.1080/14656566.2020.1717466" target="_blank" >https://www.tandfonline.com/doi/full/10.1080/14656566.2020.1717466</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1080/14656566.2020.1717466" target="_blank" >10.1080/14656566.2020.1717466</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Pharmacological strategies for the management of comorbid depression and schizophrenia

Popis výsledku v původním jazyce

Depressive symptoms may occur in any phase of schizophrenia and can have far-reaching consequences. Areas covered: The author focuses on recent reviews and meta-analyses dealing with the prevalence, importance, etiopathogenesis, and pharmacotherapy of comorbid depression and schizophrenia. Depressive symptoms in acute episodes may improve in parallel with psychosis due to antipsychotic treatment. Therefore, the first step is to evaluate the current antipsychotic treatment of psychotic symptoms and consider changing the dosage. A second step is switching antipsychotic medications, since there are indications that some medications are slightly more effective in reducing depressive symptoms than others. For persistent depressive episodes, additional therapeutic interventions are indicated. Most guidelines recommend the administration of antidepressants as an add-on treatment with a limited evidence level. Immunotherapeutic strategies could be successful, at least in some schizophrenia patients. Expert opinion: In the near future, precision psychiatry should enable clinicians to recognize specific biotypes with unique biosignatures that will guide accurate and prompt clinical management for individual patients.

Název v anglickém jazyce

Pharmacological strategies for the management of comorbid depression and schizophrenia

Popis výsledku anglicky

Depressive symptoms may occur in any phase of schizophrenia and can have far-reaching consequences. Areas covered: The author focuses on recent reviews and meta-analyses dealing with the prevalence, importance, etiopathogenesis, and pharmacotherapy of comorbid depression and schizophrenia. Depressive symptoms in acute episodes may improve in parallel with psychosis due to antipsychotic treatment. Therefore, the first step is to evaluate the current antipsychotic treatment of psychotic symptoms and consider changing the dosage. A second step is switching antipsychotic medications, since there are indications that some medications are slightly more effective in reducing depressive symptoms than others. For persistent depressive episodes, additional therapeutic interventions are indicated. Most guidelines recommend the administration of antidepressants as an add-on treatment with a limited evidence level. Immunotherapeutic strategies could be successful, at least in some schizophrenia patients. Expert opinion: In the near future, precision psychiatry should enable clinicians to recognize specific biotypes with unique biosignatures that will guide accurate and prompt clinical management for individual patients.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30104 - Pharmacology and pharmacy

Projekt

<a href="/cs/project/LQ1601" target="_blank" >LQ1601: CEITEC 2020</a><br>

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

EXPERT OPINION ON PHARMACOTHERAPY

ISSN

1465-6566

e-ISSN

—

Svazek periodika

21

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

7

Strana od-do

459-465

Kód UT WoS článku

000509444600001

EID výsledku v databázi Scopus

—