The relation between clinical phenotypes, gold groups/stages and mortality in copd patients – a prospective multicenter study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17110%2F21%3AA2202DF0" target="_blank" >RIV/61988987:17110/21:A2202DF0 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00843989:_____/21:E0108978

Výsledek na webu

<a href="https://www.dovepress.com/getfile.php?fileID=68876" target="_blank" >https://www.dovepress.com/getfile.php?fileID=68876</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2147/COPD.S297087" target="_blank" >10.2147/COPD.S297087</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The relation between clinical phenotypes, gold groups/stages and mortality in copd patients – a prospective multicenter study

Popis výsledku v původním jazyce

Introduction: The concept of phenotyping emerged, reflecting specific clinical, pulmonary and extrapulmonary features of each particular chronic obstructive pulmonary disease (COPD) case. Our aim was to analyze prognostic utility of: “Czech“ COPD phenotypes and their most frequent combinations, ”Spanish” phenotypes and Global Initiative for Chronic Obstructive Lung Disease (GOLD) stages + groups in relation to long-term mortality risk. Methods: Data were extracted from the Czech Multicenter Research Database (CMRD) of COPD. Kaplan-Meier (KM) estimates (at 60 months from inclusion) were used for mortality assessment. Survival rates were calculated for the six elementary “Czech” phenotypes and their most frequent and relevant combinations, “Spanish” phenotypes, GOLD grades and groups. Statistically significant differences were tested by Log Rank test. An analysis of factors underlying mortality risk (the role of confounders) has been assessed with the use of classification and regression tree (CART) analysis. Basic factors showing significant differences between deceased and living patients were entered into the CART model. This showed six different risk groups, the differences in risk were tested by a Log Rank test. Results: The cohort (n=720) was 73.1% men, with a mean age of 66.6 years and mean FEV1 44.4% pred.

Název v anglickém jazyce

The relation between clinical phenotypes, gold groups/stages and mortality in copd patients – a prospective multicenter study

Popis výsledku anglicky

Introduction: The concept of phenotyping emerged, reflecting specific clinical, pulmonary and extrapulmonary features of each particular chronic obstructive pulmonary disease (COPD) case. Our aim was to analyze prognostic utility of: “Czech“ COPD phenotypes and their most frequent combinations, ”Spanish” phenotypes and Global Initiative for Chronic Obstructive Lung Disease (GOLD) stages + groups in relation to long-term mortality risk. Methods: Data were extracted from the Czech Multicenter Research Database (CMRD) of COPD. Kaplan-Meier (KM) estimates (at 60 months from inclusion) were used for mortality assessment. Survival rates were calculated for the six elementary “Czech” phenotypes and their most frequent and relevant combinations, “Spanish” phenotypes, GOLD grades and groups. Statistically significant differences were tested by Log Rank test. An analysis of factors underlying mortality risk (the role of confounders) has been assessed with the use of classification and regression tree (CART) analysis. Basic factors showing significant differences between deceased and living patients were entered into the CART model. This showed six different risk groups, the differences in risk were tested by a Log Rank test. Results: The cohort (n=720) was 73.1% men, with a mean age of 66.6 years and mean FEV1 44.4% pred.

Druh

J_SC - Článek v periodiku v databázi SCOPUS

CEP obor

—

OECD FORD obor

30218 - General and internal medicine

Projekt

—

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

International Journal of COPD

ISSN

1176-9106

e-ISSN

—

Svazek periodika

16

Číslo periodika v rámci svazku

2021

Stát vydavatele periodika

NZ - Nový Zéland

Počet stran výsledku

11

Strana od-do

1171-1182

Kód UT WoS článku

—

EID výsledku v databázi Scopus

2-s2.0-85105466703