Highly Dynamic Exon Shuffling in Candidate Pathogen Receptors ? What if Brown Algae Were Capable of Adaptive Immunity?

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17310%2F12%3AA130176A" target="_blank" >RIV/61988987:17310/12:A130176A - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Highly Dynamic Exon Shuffling in Candidate Pathogen Receptors ? What if Brown Algae Were Capable of Adaptive Immunity?

Popis výsledku v původním jazyce

Pathogen recognition is often mediated by a wealth of fast-evolving receptors, many of which contain ligand-binding and signal transduction domains, such as leucine-rich or tetratricopeptide repeat (LRR/TPR) and NB-ARC domains, respectively. We mined thegenome of the brown alga Ectocarpus siliculosus for homologues of these genes and assessed the evolutionary pressures acting upon them. We thus annotated all Ectocarpus LRR-containing genes, in particular an original group of LRR-containing GTPases of the ROCO family, and 24 NB-ARC-TPR proteins. They exhibit high birth and death rates, while a diversifying selection is acting on their LRR (respectively TPR) domain, probably affecting the ligand-binding specificities. Remarkably, each repeat is encodedby an exon, and the intense exon shuffling underpins the variability of LRR and TPR domains. The Ectocarpus ROCO and NB-ARC-TPR families are thus excellent candidates for being involved in recognition/transduction events linked to immunit

Název v anglickém jazyce

Highly Dynamic Exon Shuffling in Candidate Pathogen Receptors ? What if Brown Algae Were Capable of Adaptive Immunity?

Popis výsledku anglicky

Pathogen recognition is often mediated by a wealth of fast-evolving receptors, many of which contain ligand-binding and signal transduction domains, such as leucine-rich or tetratricopeptide repeat (LRR/TPR) and NB-ARC domains, respectively. We mined thegenome of the brown alga Ectocarpus siliculosus for homologues of these genes and assessed the evolutionary pressures acting upon them. We thus annotated all Ectocarpus LRR-containing genes, in particular an original group of LRR-containing GTPases of the ROCO family, and 24 NB-ARC-TPR proteins. They exhibit high birth and death rates, while a diversifying selection is acting on their LRR (respectively TPR) domain, probably affecting the ligand-binding specificities. Remarkably, each repeat is encodedby an exon, and the intense exon shuffling underpins the variability of LRR and TPR domains. The Ectocarpus ROCO and NB-ARC-TPR families are thus excellent candidates for being involved in recognition/transduction events linked to immunit

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

<a href="/cs/project/GAP305%2F10%2F0205" target="_blank" >GAP305/10/0205: Nadrodina Ras GTPáz a evoluce eukaryotické buňky</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

MOL BIOL EVOL

ISSN

0737-4038

e-ISSN

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Svazek periodika

29

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

14

Strana od-do

1263-1276

Kód UT WoS článku

000302018100015

EID výsledku v databázi Scopus

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