Sculpting the endomembrane system in deep time: high resolution phylogenetics of Rab GTPases

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17310%2F12%3AA130176D" target="_blank" >RIV/61988987:17310/12:A130176D - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Sculpting the endomembrane system in deep time: high resolution phylogenetics of Rab GTPases

Popis výsledku v původním jazyce

We have devised and exploited a new phylogenetic strategy to reconstruct the history of the Rab GTPases, a key family of endomembrane-specificity proteins. Strikingly, we infer a remarkably sophisticated organellar composition for the last eukaryotic common ancestor, which we predict possessed as many as 23 Rab GTPases. This repertoire is significantly greater than that present in many modern organisms and indicates a major role for secondary loss in the evolutionary diversification of the endomembranesystem. Furthermore, we show that many Rab paralogues emerged relatively suddenly during early metazoan evolution, which is in stark contrast to the lack of significant Rab family expansions at the onset of most other major eukaryotic groups. Finally, wereconstruct higher-order ancestral clades of Rabs primarily linked with endocytic and exocytic process, suggesting the presence of primordial Rabs associated with the establishment of those pathways.

Název v anglickém jazyce

Sculpting the endomembrane system in deep time: high resolution phylogenetics of Rab GTPases

Popis výsledku anglicky

We have devised and exploited a new phylogenetic strategy to reconstruct the history of the Rab GTPases, a key family of endomembrane-specificity proteins. Strikingly, we infer a remarkably sophisticated organellar composition for the last eukaryotic common ancestor, which we predict possessed as many as 23 Rab GTPases. This repertoire is significantly greater than that present in many modern organisms and indicates a major role for secondary loss in the evolutionary diversification of the endomembranesystem. Furthermore, we show that many Rab paralogues emerged relatively suddenly during early metazoan evolution, which is in stark contrast to the lack of significant Rab family expansions at the onset of most other major eukaryotic groups. Finally, wereconstruct higher-order ancestral clades of Rabs primarily linked with endocytic and exocytic process, suggesting the presence of primordial Rabs associated with the establishment of those pathways.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

<a href="/cs/project/GAP305%2F10%2F0205" target="_blank" >GAP305/10/0205: Nadrodina Ras GTPáz a evoluce eukaryotické buňky</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

J CELL SCI

ISSN

0021-9533

e-ISSN

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Svazek periodika

125

Číslo periodika v rámci svazku

Pt 10

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

9

Strana od-do

2500-2508

Kód UT WoS článku

000306107000016

EID výsledku v databázi Scopus

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