Complex analyses of inverted repeats in mitochondrial genomes revealed their importance and variability
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17310%2F18%3AA1901P6O" target="_blank" >RIV/61988987:17310/18:A1901P6O - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/68081707:_____/18:00492380 RIV/62156489:43110/18:43912954
Výsledek na webu
<a href="https://academic.oup.com/bioinformatics/article/34/7/1081/4604597" target="_blank" >https://academic.oup.com/bioinformatics/article/34/7/1081/4604597</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1093/bioinformatics/btx729" target="_blank" >10.1093/bioinformatics/btx729</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Complex analyses of inverted repeats in mitochondrial genomes revealed their importance and variability
Popis výsledku v původním jazyce
MotivationThe NCBI database contains mitochondrial DNA (mtDNA) genomes from numerous species. We investigated the presence and locations of inverted repeat sequences (IRs) in these mtDNA sequences, which are known to be important for regulating nuclear genomes.ResultsIRs were identified in mtDNA in all species. IR lengths and frequencies correlate with evolutionary age and the greatest variability was detected in subgroups of plants and fungi and the lowest variability in mammals. IR presence is non-random and evolutionary favoured. The frequency of IRs generally decreased with IR length, but not for IRs 24 or 30?bp long, which are 1.5 times more abundant. IRs are enriched in sequences from the replication origin, followed by D-loop, stem-loop and miscellaneous sequences, pointing to the importance of IRs in regulatory regions of mitochondrial DNA.Availability and ImplementationData were produced using Palindrome analyser, freely available on the web at http://bioinformatics.ibp.cz.
Název v anglickém jazyce
Complex analyses of inverted repeats in mitochondrial genomes revealed their importance and variability
Popis výsledku anglicky
MotivationThe NCBI database contains mitochondrial DNA (mtDNA) genomes from numerous species. We investigated the presence and locations of inverted repeat sequences (IRs) in these mtDNA sequences, which are known to be important for regulating nuclear genomes.ResultsIRs were identified in mtDNA in all species. IR lengths and frequencies correlate with evolutionary age and the greatest variability was detected in subgroups of plants and fungi and the lowest variability in mammals. IR presence is non-random and evolutionary favoured. The frequency of IRs generally decreased with IR length, but not for IRs 24 or 30?bp long, which are 1.5 times more abundant. IRs are enriched in sequences from the replication origin, followed by D-loop, stem-loop and miscellaneous sequences, pointing to the importance of IRs in regulatory regions of mitochondrial DNA.Availability and ImplementationData were produced using Palindrome analyser, freely available on the web at http://bioinformatics.ibp.cz.
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
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OECD FORD obor
10600 - Biological sciences
Návaznosti výsledku
Projekt
<a href="/cs/project/GA15-21855S" target="_blank" >GA15-21855S: Vliv konformačních motivů a epigenetických modifikací na DNA vazebné vlastnosti proteinů rodiny p53</a><br>
Návaznosti
S - Specificky vyzkum na vysokych skolach
Ostatní
Rok uplatnění
2018
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
BIOINFORMATICS
ISSN
1367-4803
e-ISSN
1460-2059
Svazek periodika
34
Číslo periodika v rámci svazku
7
Stát vydavatele periodika
GB - Spojené království Velké Británie a Severního Irska
Počet stran výsledku
5
Strana od-do
1081-1085
Kód UT WoS článku
000428840000001
EID výsledku v databázi Scopus
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