DNA polymerase eta mutational signatures are found in a variety of different types of cancer.

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17310%2F18%3AA1901X0W" target="_blank" >RIV/61988987:17310/18:A1901X0W - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1080/15384101.2017.1404208" target="_blank" >http://dx.doi.org/10.1080/15384101.2017.1404208</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1080/15384101.2017.1404208" target="_blank" >10.1080/15384101.2017.1404208</a>

Jazyk výsledku

angličtina

Název v původním jazyce

DNA polymerase eta mutational signatures are found in a variety of different types of cancer.

Popis výsledku v původním jazyce

DNA polymerase (pol) is a specialized error-prone polymerase with at least two quite different and contrasting cellular roles: to mitigate the genetic consequences of solar UV irradiation, and promote somatic hypermutation in the variable regions of immunoglobulin genes. Misregulation and mistargeting of pol can compromise genome integrity. We explored whether the mutational signature of pol could be found in datasets of human somatic mutations derived from normal and cancer cells. A substantial excess of single and tandem somatic mutations within known pol mutable motifs was noted in skin cancer as well as in many other types of human cancer, suggesting that somatic mutations in A:T bases generated by DNA polymerase are a common feature of tumorigenesis. Another peculiarity of pol mutational signatures, mutations in YCG motifs, led us to speculate that error-prone DNA synthesis opposite methylated CpG dinucleotides by misregulated pol in tumors might constitute an additional mechanism of cytosine demethylation in this hypermutable dinucleotide.

Název v anglickém jazyce

DNA polymerase eta mutational signatures are found in a variety of different types of cancer.

Popis výsledku anglicky

DNA polymerase (pol) is a specialized error-prone polymerase with at least two quite different and contrasting cellular roles: to mitigate the genetic consequences of solar UV irradiation, and promote somatic hypermutation in the variable regions of immunoglobulin genes. Misregulation and mistargeting of pol can compromise genome integrity. We explored whether the mutational signature of pol could be found in datasets of human somatic mutations derived from normal and cancer cells. A substantial excess of single and tandem somatic mutations within known pol mutable motifs was noted in skin cancer as well as in many other types of human cancer, suggesting that somatic mutations in A:T bases generated by DNA polymerase are a common feature of tumorigenesis. Another peculiarity of pol mutational signatures, mutations in YCG motifs, led us to speculate that error-prone DNA synthesis opposite methylated CpG dinucleotides by misregulated pol in tumors might constitute an additional mechanism of cytosine demethylation in this hypermutable dinucleotide.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

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OECD FORD obor

10601 - Cell biology

Projekt

—

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

CELL CYCLE

ISSN

1538-4101

e-ISSN

—

Svazek periodika

17

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

8

Strana od-do

348-355

Kód UT WoS článku

000430207100014

EID výsledku v databázi Scopus

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