Common structural patterns in the maxicircle divergent region of Trypanosomatidae

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17310%2F20%3AA21025CX" target="_blank" >RIV/61988987:17310/20:A21025CX - isvavai.cz</a>

Výsledek na webu

<a href="https://www.mdpi.com/2076-0817/9/2/100/htm" target="_blank" >https://www.mdpi.com/2076-0817/9/2/100/htm</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/pathogens9020100" target="_blank" >10.3390/pathogens9020100</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Common structural patterns in the maxicircle divergent region of Trypanosomatidae

Popis výsledku v původním jazyce

Maxicircles of all kinetoplastid flagellates are functional analogs of mitochondrial genome of other eukaryotes. They consist of two distinct parts, called the coding region and the divergent region (DR). The DR is composed of highly repetitive sequences and, as such, remains the least explored segment of a trypanosomatid genome. It is extremely difficult to sequence and assemble, that is why very few full length maxicircle sequences were available until now. Using PacBio data, we assembled 17 complete maxicircles from different species of trypanosomatids. Here we present their large-scale comparative analysis and describe common patterns of DR organization in trypanosomatids.

Název v anglickém jazyce

Common structural patterns in the maxicircle divergent region of Trypanosomatidae

Popis výsledku anglicky

Maxicircles of all kinetoplastid flagellates are functional analogs of mitochondrial genome of other eukaryotes. They consist of two distinct parts, called the coding region and the divergent region (DR). The DR is composed of highly repetitive sequences and, as such, remains the least explored segment of a trypanosomatid genome. It is extremely difficult to sequence and assemble, that is why very few full length maxicircle sequences were available until now. Using PacBio data, we assembled 17 complete maxicircles from different species of trypanosomatids. Here we present their large-scale comparative analysis and describe common patterns of DR organization in trypanosomatids.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30109 - Pathology

Projekt

<a href="/cs/project/EF16_019%2F0000759" target="_blank" >EF16_019/0000759: Centrum výzkumu patogenity a virulence parazitů</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

PATHOGENS

ISSN

2076-0817

e-ISSN

2076-0817

Svazek periodika

9

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

17

Strana od-do

100

Kód UT WoS článku

000519242900055

EID výsledku v databázi Scopus

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