The catalytic domain of the histone methyltransferase NSD2/MMSET is required for the generation of B1 cells in mice

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17310%2F20%3AA21026IV" target="_blank" >RIV/61988987:17310/20:A21026IV - isvavai.cz</a>

Výsledek na webu

<a href="https://febs.onlinelibrary.wiley.com/doi/full/10.1002/1873-3468.13903" target="_blank" >https://febs.onlinelibrary.wiley.com/doi/full/10.1002/1873-3468.13903</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/1873-3468.13903" target="_blank" >10.1002/1873-3468.13903</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The catalytic domain of the histone methyltransferase NSD2/MMSET is required for the generation of B1 cells in mice

Popis výsledku v původním jazyce

Humoral immunity in mammals relies on the function of two developmentally and functionally distinct B-cell subsets-B1 and B2 cells. While B2 cells are responsible for the adaptive response to environmental antigens, B1 cells regulate the production of polyreactive and low-affinity antibodies for innate humoral immunity. The molecular mechanism of B-cell specification into different subsets is understudied. In this study, we identified lysine methyltransferase NSD2 (MMSET/WHSC1) as a critical regulator of B1 cell development. In contrast to its minor impact on B2 cells, deletion of the catalytic domain of NSD2 in primary B cells impairs the generation of B1 lineage. Thus, NSD2, a histone H3 K36 dimethylase, is the first-in-class epigenetic regulator of a B-cell lineage in mice.

Název v anglickém jazyce

The catalytic domain of the histone methyltransferase NSD2/MMSET is required for the generation of B1 cells in mice

Popis výsledku anglicky

Humoral immunity in mammals relies on the function of two developmentally and functionally distinct B-cell subsets-B1 and B2 cells. While B2 cells are responsible for the adaptive response to environmental antigens, B1 cells regulate the production of polyreactive and low-affinity antibodies for innate humoral immunity. The molecular mechanism of B-cell specification into different subsets is understudied. In this study, we identified lysine methyltransferase NSD2 (MMSET/WHSC1) as a critical regulator of B1 cell development. In contrast to its minor impact on B2 cells, deletion of the catalytic domain of NSD2 in primary B cells impairs the generation of B1 lineage. Thus, NSD2, a histone H3 K36 dimethylase, is the first-in-class epigenetic regulator of a B-cell lineage in mice.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

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OECD FORD obor

10608 - Biochemistry and molecular biology

Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

FEBS LETTERS

ISSN

0014-5793

e-ISSN

1873-3468

Svazek periodika

594

Číslo periodika v rámci svazku

20

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

14

Strana od-do

3324-3337

Kód UT WoS článku

000564214800001

EID výsledku v databázi Scopus

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