Ku80 is involved in telomere maintenance but dispensable for genomic stability in Leishmania mexicana

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17310%2F21%3AA2202CAM" target="_blank" >RIV/61988987:17310/21:A2202CAM - isvavai.cz</a>

Výsledek na webu

<a href="https://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0010041" target="_blank" >https://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0010041</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1371/journal.pntd.0010041" target="_blank" >10.1371/journal.pntd.0010041</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Ku80 is involved in telomere maintenance but dispensable for genomic stability in Leishmania mexicana

Popis výsledku v původním jazyce

Author summaryParasites of the genus Leishmania cause leishmaniasis, a neglected tropical disease. Telomeric and sub-telomeric regions of these flagellates are often associated with virulence. That is why studying telomere maintenance is important. Here we demonstrate that deletion of one of the proteins, implicated in telomere maintenance, resulted in elongated telomeres. This is unexpected, because deletion of the same gene in another model organism, Trypanosoma brucei, has an opposite effect. Previous comparative genomic studies suggested that the protein under study might be also involved in genome stability. Nevertheless, we did not detect any trace of genomic instability in L. mexicana after 100 passages. We concluded that Ku80 is involved in telomere maintenance but dispensable for genomic stability in Leishmania mexicana.

Název v anglickém jazyce

Ku80 is involved in telomere maintenance but dispensable for genomic stability in Leishmania mexicana

Popis výsledku anglicky

Author summaryParasites of the genus Leishmania cause leishmaniasis, a neglected tropical disease. Telomeric and sub-telomeric regions of these flagellates are often associated with virulence. That is why studying telomere maintenance is important. Here we demonstrate that deletion of one of the proteins, implicated in telomere maintenance, resulted in elongated telomeres. This is unexpected, because deletion of the same gene in another model organism, Trypanosoma brucei, has an opposite effect. Previous comparative genomic studies suggested that the protein under study might be also involved in genome stability. Nevertheless, we did not detect any trace of genomic instability in L. mexicana after 100 passages. We concluded that Ku80 is involved in telomere maintenance but dispensable for genomic stability in Leishmania mexicana.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

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OECD FORD obor

10603 - Genetics and heredity (medical genetics to be 3)

Projekt

<a href="/cs/project/EF16_019%2F0000759" target="_blank" >EF16_019/0000759: Centrum výzkumu patogenity a virulence parazitů</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

PLOS NEGLECT TROP D

ISSN

1935-2735

e-ISSN

—

Svazek periodika

15

Číslo periodika v rámci svazku

12

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

15

Strana od-do

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Kód UT WoS článku

000738780800002

EID výsledku v databázi Scopus

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